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PNU 282987

Cat No. 2303

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Chemical Name: N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide

Biological Activity

Highly selective α7 nAChR agonist (K_i = 26 nM) displaying negligible blockade of α₁β₁γδ and α₃β₄ nAChRs (IC₅₀ ≥ 60 μM). Found to be inactive against a panel of 32 receptors at 1 μM, except 5-HT₃ receptors (K_i = 930 nM).

Technical Data

M.Wt:

264.75

Formula:

C₁₄H₁₇ClN₂O

Solubility:

Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at RT

CAS No:

[123464-89-1]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

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Material Safety Data Sheet: View current batch

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References

Bodnar et al (2005) Discovery and structure-activity relationship of quinuclidine benzamides as agonists of a7 nicotinic acetylcholine receptors. J.Med.Chem. 48 905. Hajós et al (2005) The selective a7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats. J.Pharmacol.Exp.Ther. 312 1213.

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