Cat. No. 2293
Alternative Name: NSC 309132
Chemical Name: 1-β-D-Ribofuranosyl-2(1H)-pyrimidino
Biological ActivityOrally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Inhibits cytidine deaminase (Ki ~ 2 μM); induces differentiation of mesenchymal stem cells into cardiomyocytes.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Laliberte et al (1992) Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase. Cancer Chemother.Pharmacol. 30 7. PMID: 1375134.
Ben-Kasus et al (2005) Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells. Biochem.Pharmacol. 70 121. PMID: 15885659.
Naeem et al (2012) DNA methylation inhibitors, 5-azacytidine and zebularine potentiate the trans-differentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes. Cardiovasc.Ther. [Epub ahead of print].
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: Zebularine, supplier, DNA, methyltransferase, inhibitors, Transferases, cytidine, deaminases, NSC309132, dnmt, cardiomyocyte, differentiation, mesenchymal, stem, cells, epigenetics
Find multiple products by catalog number
New Products in this Area
Highly potent Porcn inhibitorUNC 0642
Potent and selective G9a and GLP histone lysine methyltransferase inhibitor(R)-PFI 2 hydrochloride
Potent and selective SETD7 histone lysine methyltransferase inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.