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Zebularine

Cat. No. 2293

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Alternative Name: NSC 309132

Chemical Name: 1-β-D-Ribofuranosyl-2(1H)-pyrimidinone

Biological Activity

Orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC₅₀ = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Inhibits cytidine deaminase (K_i ~ 2 μM); induces differentiation of mesenchymal stem cells into cardiomyocytes.

Technical Data

M.Wt:

228.2

Formula:

C₉H₁₂N₂O₅

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at RT

CAS No:

3690-10-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Laliberte et al (1992) Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase. Cancer Chemother.Pharmacol. 30 7. PMID: 1375134.

Ben-Kasus et al (2005) Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells. Biochem.Pharmacol. 70 121. PMID: 15885659.

Naeem et al (2012) DNA methylation inhibitors, 5-azacytidine and zebularine potentiate the trans-differentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes. Cardiovasc.Ther. [Epub ahead of print].

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Keywords: Zebularine, supplier, DNA, methyltransferase, inhibitors, Transferases, cytidine, deaminases, NSC309132, dnmt, cardiomyocyte, differentiation, mesenchymal, stem, cells, epigenetics