R&D Systems Inc. Tocris Bioscience Boston Biochem

Zebularine

Cat. No. 2293

Zebularine C9H12N2O5 [3690-10-6]

Price and Availability

For Zebularine pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: NSC 309132

Chemical Name: 1-β-D-Ribofuranosyl-2(1H)-pyrimidinone

Biological Activity

Orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Inhibits cytidine deaminase (Ki ~ 2 μM); induces differentiation of mesenchymal stem cells into cardiomyocytes.

Technical Data

M.Wt:
228.2
Formula:
C9H12N2O5
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
3690-10-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Laliberte et al (1992) Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase. Cancer Chemother.Pharmacol. 30 7. PMID: 1375134.

Ben-Kasus et al (2005) Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells. Biochem.Pharmacol. 70 121. PMID: 15885659.

Naeem et al (2012) DNA methylation inhibitors, 5-azacytidine and zebularine potentiate the trans-differentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes. Cardiovasc.Ther. [Epub ahead of print].

If you know of a relevant citation for this product please let us know.

Keywords: Zebularine, supplier, DNA, methyltransferase, inhibitors, Transferases, cytidine, deaminases, NSC309132, dnmt, cardiomyocyte, differentiation, mesenchymal, stem, cells, epigenetics

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Epigenetics Research Bulletin

Epigenetics Research Bulletin

Includes up to date information and products for epigenetics research. View PDF today.

divider line

New Product Guide

NPG

Highlights over 130 new products added in the second half of 2013. Request a copy or view PDF today.

divider line

New Products in this Area

Wnt-C59

Highly potent Porcn inhibitor

UNC 0642

Potent and selective G9a and GLP histone lysine methyltransferase inhibitor

(R)-PFI 2 hydrochloride

Potent and selective SETD7 histone lysine methyltransferase inhibitor

Sign-up for new product e-alerts
divider line

Bio-Techne Events

Federation of European Physiologists Meeting 2014

Federation of European Physiologists Meeting 2014

August 27 - 30, 2014

Budapest, Hungary