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Sibutramine hydrochloride

Cat. No. 2290

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Alternative Name: BTS 54-524

Chemical Name: 1-(4-Chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)cyclobutanemethanamine hydrochloride

Biological Activity

5-HT and noradrenalin re-uptake inhibitor (SNRI). Produces weight loss in rats via inhibition of food intake and increased energy expenditure. Antidepressant.

Technical Data

M.Wt:

316.31

Formula:

C₁₇H₂₆NCl.HCl

Solubility:

Soluble to 5 mM in water and to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at RT

CAS No:

84485-00-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Buckett et al (1988) The pharmacology of sibutramine hydrochloride (BTS 54524), a new antidepressant which induces rapid noradrenergic down-regulation. Prog.Neuro-Psychopharm.Biol.Psychiat. 12 575.

Gundlah et al (1997) In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutramine is a reuptake inhibitor. J.Pharmacol.Exp.Ther. 283 581. PMID: 9353373.

Jackson et al (1997) Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat. Br.J.Pharmacol. 121 1758. PMID: 9283714.

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