R&D Systems Inc. Tocris Bioscience Boston Biochem

DH 97

Cat. No. 1218

DH 97 C22H26N2O [220339-00-4]

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Chemical Name: N-Pentanoyl-2-benzyltryptamine

Biological Activity

A relatively potent MT2 melatonin receptor antagonist (pKi value = 8.03), displaying 89- and 229-fold selectivity over MT1 and GPR50 (melatonin-related orphan receptor) respectively.

Technical Data

M.Wt:
334.46
Formula:
C22H26N2O
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at RT
CAS No:
220339-00-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Teh and Sugden (1998) Comparison of the relationships of melatonin receptor agonists and antagonists; lengthening the N-acyl side chain has differing effects on potency on Xenopus melanophores. Naunyn Schmiedebergs Arch.Pharmacol. 358 522. PMID: 9840420.

Ting et al (1999) Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar rats. Br.J.Pharmacol. 127 987. PMID: 10433507.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: DH 97, supplier, MT2, receptor, antagonist, Receptors, Melatonin, DH97

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