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DH 97

Cat. No. 1218

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Chemical Name: N-Pentanoyl-2-benzyltryptamine

Biological Activity

A relatively potent MT₂ melatonin receptor antagonist (pK_i value = 8.03), displaying 89- and 229-fold selectivity over MT₁ and GPR50 (melatonin-related orphan receptor) respectively.

Technical Data

M.Wt:

334.46

Formula:

C₂₂H₂₆N₂O

Solubility:

Soluble to 100 mM in DMSO

Storage:

Store at RT

CAS No:

220339-00-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Teh and Sugden (1998) Comparison of the relationships of melatonin receptor agonists and antagonists; lengthening the N-acyl side chain has differing effects on potency on Xenopus melanophores. Naunyn Schmiedebergs Arch.Pharmacol. 358 522. PMID: 9840420.

Ting et al (1999) Molecular and pharmacological evidence for MT₁ melatonin receptor subtype in the tail artery of juvenile Wistar rats. Br.J.Pharmacol. 127 987. PMID: 10433507.

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7-TM Receptor Signaling

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'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy