Cat. No. 1218
Chemical Name: N-Pentanoyl-2-benzyltryptamine
Biological ActivityA relatively potent MT2 melatonin receptor antagonist (pKi value = 8.03), displaying 89- and 229-fold selectivity over MT1 and GPR50 (melatonin-related orphan receptor) respectively.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Teh and Sugden (1998) Comparison of the relationships of melatonin receptor agonists and antagonists; lengthening the N-acyl side chain has differing effects on potency on Xenopus melanophores. Naunyn Schmiedebergs Arch.Pharmacol. 358 522. PMID: 9840420.
Ting et al (1999) Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar rats. Br.J.Pharmacol. 127 987. PMID: 10433507.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: DH 97, supplier, MT2, receptor, antagonist, Receptors, Melatonin, DH97
Find multiple products by catalog number
New Products in this Area
Potent and selective human CCR2 antagonistTY 52156
S1P3 receptor antagonistElinogrel
P2Y12 antagonistRactopamine hydrochloride
Trace amine 1 (TA1) receptor agonistTG 4-155
High affinity and selective EP2 receptor antagonistSAG
Potent Smoothened receptor agonist; activates the Hedgehog signaling pathwayDC 260126
FFA1 (GPR40) antagonistAR-C 118925XX
Selective, competitive P2Y2 receptor antagonist
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.