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Lactacystin

Cat No. 2267

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Biological Activity

A cell-permeable, potent and selective proteasome inhibitor. A Streptomyces metabolite that is thought to bind irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Induces neurite outgrowth in Neuro 2a neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC₅₀ = 10 μM).

Technical Data

M.Wt:

376.42

Formula:

C₁₅H₂₄N₂O₇S

Storage:

Desiccate at -20°C

CAS No:

[133343-34-7]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

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Material Safety Data Sheet: View current batch

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References

Omura et al (1991) Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells. J.Antibiot. 44 113. Fenteany et al (1995) Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 268 726. Bellas et al (1997) Inhibition of NF-kappa B activity induces apoptosis in murine hepatocytes. Am.J.Pathol. 151 891.

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