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LactacystinCat No. 2267 |
Price and Availability |
Biological Activity
A cell-permeable, potent and selective proteasome inhibitor. A Streptomyces metabolite that is thought to bind irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Induces neurite outgrowth in Neuro 2a neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC50 = 10 μM).Technical Data
M.Wt:376.42
Formula:C15H24N2O7S
Storage:Desiccate at -20°C
CAS No:[133343-34-7]
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
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References
Omura et al (1991) Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells. J.Antibiot. 44 113. Fenteany et al (1995) Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 268 726. Bellas et al (1997) Inhibition of NF-kappa B activity induces apoptosis in murine hepatocytes. Am.J.Pathol. 151 891.If you know of a useful citation for this product please let us know.
Keywords: Lactacystin, Cell-permeable, potent, selective, proteasome, inhibitors, Proteasome, Proteinases, Proteases
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