R&D Systems Inc. Tocris Bioscience Boston Biochem

Doxorubicin hydrochloride

Cat. No. 2252

Doxorubicin hydrochloride C27H29NO11.HCl [25316-40-9]

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Alternative Names: Adriamycin, NSC 123127

Chemical Name: 10-[(3-Amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride

Biological Activity

Antitumor antibiotic agent that inhibits DNA topoisomerase II. DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis. Reduces intracellular tau levels.

Technical Data

M.Wt:
579.99
Formula:
C27H29NO11.HCl
Solubility:
Soluble to 50 mM in water
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
25316-40-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Skladanowski and Konopa (1993) Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells. Biochem.Pharmacol. 46 357. PMID: 8347161.

Patel et al (1997) Identification of yeast DNA topoisomerase II mutants resistant to the antitumor drug doxorubicin: implications for the mechanisms of doxorubicin action and cyotoxicity. Mol.Pharmacol. 52 658. PMID: 9380029.

Gewirtz (1999) A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem.Pharmacol. 57 727. PMID: 10075079.

Dickey et al (2006) Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression. Mol.Neurodegen. 1 6. PMID: 16930453.

If you know of a relevant citation for this product please let us know.

Keywords: Doxorubicin hydrochloride, supplier, Antitumor, antibiotics, agent, inhibitors, DNA, topoisomerase, II, Isomerases, NSC123127

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