CisplatinCat No. 2251 |
Price and Availability |
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Alternative Name: CDDP Chemical Name: cis-Diaminodichloroplatinum |
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Biological Activity
Potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF-α-induced apoptosis.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Seki et al (2000) Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma. Cancer Chemother.Pharmacol. 45 199. Duan et al (2004) Impairment of both apoptotic and cytoprotective signalings in glioma cells resistant to the combined use of cisplatin and tumor necrosis factor a. Clin.Cancer Res. 10 234. Nomura et al (2004) Cisplatin inhibits the expression of X-linked inhibitor of apoptosis protein in human LNCaP cells. Urol.Oncology 22 453.If you know of a useful citation for this product please let us know.
Keywords: Cisplatin, Potent, proapoptotic, anticancer, agent, activates, caspase-3, DNA-alkylating, antitumor, agent, Caspases, Apoptosis, Inducers, Proteinases, Proteases
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