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Quercetin

Cat. No. 1125

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Chemical Name: 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one

Biological Activity

Antitumor agent; induces apoptosis and inhibits synthesis of heat shock proteins. Inhibits many enzyme systems including tyrosine protein kinase, phospholipase A₂, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C. Can also activate Ca²⁺ and K⁺ channels and behaves as an agonist at estrogen (GPR30) receptors.

Technical Data

M.Wt:

302.24

Formula:

C₁₅H₁₀O₇

Solubility:

Soluble to 100 mM in DMSO

Storage:

Store at RT

CAS No:

117-39-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Merck Index 12 8216.

Graziani et al (1983) The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo. J.Biochem. 135 583. PMID: 6311542.

Levy et al (1984) Tyrosine protein kinase activity in the DMBA-induced rat mammary tumor: inhibition by quercetin. Biochem.Biophys.Res.Commun. 123 1227. PMID: 6091650.

Wei et al (1994) Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Res. 54 4952. PMID: 8069862.

Cermak et al (2002) The flavonol quercetin activates basolateral K⁺ channels in rat distal colon epithelium. Br.J.Pharmacol. 135 1183. PMID: 11877325.

Saponara et al (2002) Quercetin as a novel activator of L-type Ca²⁺ channels in rat tail artery smooth muscle cells. Br.J.Pharmacol. 135 1819. PMID: 11934824.

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Keywords: Quercetin, supplier, Non-Selective, PI, 3-kinase, inhibitors, GPR30, agonists, non-selective, 3-Kinase, PI3K, Akt, Signaling, Signalling, PIP2, Inositol, Lipids, cAMP, Receptors, Estrogen, receptors, Phosphoinositide, Kinases

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7-TM Receptor Signaling

Written by T. Kenakin et al

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy

Estrogen Pathway

Estrogen controls many cellular processes including growth, differentiation and function of the reproductive system. View pathway or download PDF today.