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Urotensin II-related peptide

Cat. No. 2215

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Biological Activity

Potent endogenous agonist for the urotensin-II (UT) receptor. Binds with high affinity and potently activates recombinant rat and human UT receptors (EC₅₀ values are 0.55 and 4.8 nM respectively). Produces hypotensive effects following systemic administration in rats.

Technical Data

M.Wt:

1017.23

Formula:

C₄₉H₆₆N₁₀O₁₀S₂

Sequence:

ACFWKYCV

(Modifications: Disulfide bridge between 2 - 7)

Solubility:

Soluble to 1 mg/ml in 5% acetonitrile / water

Storage:

Desiccate at -20°C

CAS No:

342878-90-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Sugo et al (2003) Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain. Biochem.Biophys.Res.Comm. 310 860.

Chatenet et al (2004) Structure-activity relationships and structural conformation of a novel urotensin II-related peptide. Peptides 25 1819. PMID: 15476952.

Mori and Fujino (2004) Urotensin II-related peptide, the endogenous ligand for the urotensin II receptor in the rat brain. Peptides 25 1815. PMID: 15476951.

If you know of a relevant citation for this product please let us know.

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