Home » Research Area » » Ion Channels » Ligand-gated Ion Channels » Glutamate (Ionotropic) Receptors » NMDA Receptors » N20C hydrochloride

N20C hydrochloride

Cat. No. 2213

Price and Availability

For N20C hydrochloride pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 2-[(3,3-Diphenylpropyl)amino]acetamide hydrochloride

Biological Activity

Selective, non-competitive NMDA receptor antagonist (IC₅₀ = 5 μM); binds to the receptor-associated ion channel and prevents glutamate-induced Ca²⁺ influx. Displays neuroprotective activity in vivo. Brain-penetrant.

Technical Data

M.Wt:

304.82

Formula:

C₁₇H₂₀N₂O.HCl

Solubility:

Soluble to 100 mM in water

Purity:

>98 %

Storage:

Desiccate at +4°C

CAS No:

76991-05-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Planells-Cases et al (2002) A novel N-methyl-D-aspartate receptor open channel blocker with in vivo neuroprotectant activity. J.Pharmacol.Exp.Ther. 302 163. PMID: 12065713.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Glutamate (Ionotropic) Receptors

NMDA Receptors

Keywords: N20C hydrochloride, supplier, Non-competitive, NMDA, receptor, open-channel, blockers, glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic

Quick Order

Find multiple products by catalog number

Pain Research Product Guide

Highlights over 280 products for Pain research. Request copy or view PDF today.

Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

'Schizophrenia - Emerging Targets and Therapeutic Strategies' provides a summary of the targets and pathways representing the most promising strategies to pursue for novel drug development.

Calcium Imbalance and Neuroprotective Targets

Written by E. Besancon et al

'Calcium Imbalance and Neuro-protective Targets in Cerebral Ischemia & Brain Injury' highlights the key targets involved in stroke, trauma and neurodegeneration.

Neurobiology of Parkinson's Disease

Written by A. Schapira

'Neurobiology and Therapeutics of Parkinson's Disease' highlights the neurobiology of Parkinson's disease and summarizes current and novel therapeutic interventions.