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PD 160170

Cat. No. 2200

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Chemical Name: 6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine

Biological Activity

Potent, selective non-peptidic neuropeptide Y₁ receptor antagonist (K_i = 48 nM); selective over Y₂ and Y₅ receptors (K_i > 10 μM). Antagonizes NPY-mediated inhibition of cAMP accumulation in SK-N-MC cells (IC₅₀ = 8.2 nM).

Technical Data

M.Wt:

371.41

Formula:

C₁₈H₁₇N₃O₄S

Solubility:

Soluble to 100 mM in DMSO

Purity:

>98 %

Storage:

Store at RT

CAS No:

181468-88-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Wright et al (1996) 8-Amino-6-(arylsulphonyl)-5-nitroquinolines: novel nonpeptide neuropeptide Y1 receptor antagonists. Bioorg.Med.Chem.Lett. 6 1809.

Wielgosz-Collin et al (2002) 8-Amino-5-nitro-6-phenoxyquinolines:potential non-peptidic neuropeptide Y receptor ligands. J.Enz.Inhib.Med.Chem. 17 449.

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