R&D Systems Inc. Tocris Bioscience Boston Biochem

L-755,507

Cat. No. 2197

L-755,507 C30H40N4O6S [159182-43-1]

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Chemical Name: 4-[[(Hexylamino)carbonyl]amino]-N-[­4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]a­mino]ethyl]phenyl]-benzenesulfonamide

Biological Activity

Potent β3-adrenergic receptor partial agonist > 1000-fold selective over β1- and β2-adrenoceptors (EC50 values are 0.43, 580 and > 10000 nM for activation of cloned human β3-, β1- and β2-adrenoceptors respectively). Stimulates lipolysis in rhesus adipocytes in vitro (EC50 = 3.9 nM).

Technical Data

M.Wt:
584.73
Formula:
C30H40N4O6S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
159182-43-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Fisher et al (1998) A selective human β3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys. J.Clin.Invest. 101 2387. PMID: 9616210.

Parmee et al (1998) Discovery of L-755,507: a subnanomolar human β3 adrenergic receptor agonist. Bioorg.Med.Chem.Lett. 8 1107. PMID: 9871717.

If you know of a relevant citation for this product please let us know.

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