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Mifepristone

Cat. No. 1479

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Alternative Names: RU 486, RU 38486

Chemical Name: (11β,17β)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one

Biological Activity

Selective antagonist at progesterone (PR) and glucocorticoid (GR) receptors in vitro and in vivo. Is a silent antagonist at PR and has a higher affinity than progesterone. Has higher affinity for GR than dexamethasone.

Technical Data

M.Wt:

429.6

Formula:

C₂₉H₃₅NO₂

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol with gentle warming

Purity:

>99 %

Storage:

Store at RT

CAS No:

84371-65-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Schrieber et al (1983) Binding of the anti-progestin RU 486 to rat ovary steroid receptors. Contraception 28 77. PMID: 6627946.

Gagne et al (1985) RU 38486: a potent antiglucocorticoid in vitro and in vivo. J.Steroid Biochem. 23 247. PMID: 2864478.

Mao et al (1992) Molecular mechanism of RU 486 action: a review. Mol.Cell.Biochem. 109 1. PMID: 1614417.

If you know of a relevant citation for this product please let us know.

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Keywords: Mifepristone, supplier, Glucocorticoid, progesterone, antagonists, glucocorticoid, Receptors, RU486, RU38486

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