R&D Systems Inc. Tocris Bioscience Boston Biochem

Gap 27

Cat. No. 1476

Gap 27 Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile

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Biological Activity

Peptide derived from connexin 43 that is a selective gap junction blocker. Attenuates ACh-induced arterial relaxation and reduces K+-mediated smooth muscle repolarization in endothelium-intact vessels in vitro.

Technical Data

M.Wt:
1304.55
Formula:
C60H101N15O17
Sequence:
SRPTEKTIFII
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
198284-64-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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References

Chaytor et al (1998) Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. J.Physiol. 508 561. PMID: 9508817.

Ko et al (2000) Biochemical and functional characterization of intercellular adhesion and gap junctions in fibroblasts. Am.J.Physiol.Cell Physiol. 279 C147. PMID: 10898726.

Richards et al (2001) Suppression of K+-induced hyperpolarization by phenylephrine in rat mesenteric artery: relevance to studies of endothelium-derived hyperpolarizing factor. Br.J.Pharmacol. 134 1. PMID: 11522590.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Gap 27, supplier, Selective, gap, junction, blockers, Connexins, Gap, Channels, modulators, Gap27

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