Cat. No. 1476
Biological ActivityPeptide derived from connexin 43 that is a selective gap junction blocker. Attenuates ACh-induced arterial relaxation and reduces K+-mediated smooth muscle repolarization in endothelium-intact vessels in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Chaytor et al (1998) Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. J.Physiol. 508 561. PMID: 9508817.
Ko et al (2000) Biochemical and functional characterization of intercellular adhesion and gap junctions in fibroblasts. Am.J.Physiol.Cell Physiol. 279 C147. PMID: 10898726.
Richards et al (2001) Suppression of K+-induced hyperpolarization by phenylephrine in rat mesenteric artery: relevance to studies of endothelium-derived hyperpolarizing factor. Br.J.Pharmacol. 134 1. PMID: 11522590.
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Keywords: Gap 27, supplier, Selective, gap, junction, blockers, Connexins, Gap, Channels, modulators, Gap27
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