Cat. No. 1476
Biological ActivityPeptide derived from connexin 43 that is a selective gap junction blocker. Attenuates ACh-induced arterial relaxation and reduces K+-mediated smooth muscle repolarization in endothelium-intact vessels in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Chaytor et al (1998) Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. J.Physiol. 508 561. PMID: 9508817.
Ko et al (2000) Biochemical and functional characterization of intercellular adhesion and gap junctions in fibroblasts. Am.J.Physiol.Cell Physiol. 279 C147. PMID: 10898726.
Richards et al (2001) Suppression of K+-induced hyperpolarization by phenylephrine in rat mesenteric artery: relevance to studies of endothelium-derived hyperpolarizing factor. Br.J.Pharmacol. 134 1. PMID: 11522590.
If you know of a relevant citation for this product please let us know.
View Related Products by Product Action
Keywords: Gap 27, supplier, Selective, gap, junction, blockers, Connexins, Gap, Channels, modulators, Gap27, Tocris Bioscience, Gap Channel Blockers
Find multiple products by catalog number
New Products in this Area
Potent and selective GRK2/3 inhibitorPMX 53c
Negative control for PMX 53 (Cat. No. 5473)W 54011
High affinity C5a receptor antagonist
March 19 - 23, 2016
Denver, CO, USA