Cat. No. 2897
Chemical Name: 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide
Biological ActivityNon-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity. Does not inhibit other small GTPases. Blocks endocytic pathways dependent on dynamin and inhibits cell spreading and migration of BSC1 cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Macia et al (2006) Dynasore, a cell-permeable inhibitor of Dynamin. Develop.Cell 10 839.
Newton et al (2006) Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis. Proc.Natl.Acad.Sci.USA 103 17955.
Thompson and McNiven (2006) Discovery of a new 'dynasore'. Nat.Chem.Biol. 2 355. PMID: 16783339.
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Keywords: Dynasore, supplier, Non-competitive, dynamin, 1, 2, mitochondrial, Drp1, inhibitors, Mitosis, GTPases