R&D Systems Inc. Tocris Bioscience Boston Biochem

Dynasore

Cat. No. 2897

Dynasore C18H14N2O4 [304448-55-3]

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Chemical Name: 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide

Biological Activity

Non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity. Does not inhibit other small GTPases. Blocks endocytic pathways dependent on dynamin and inhibits cell spreading and migration of BSC1 cells.

Technical Data

M.Wt:
322.32
Formula:
C18H14N2O4
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
304448-55-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Macia et al (2006) Dynasore, a cell-permeable inhibitor of Dynamin. Develop.Cell 10 839.

Newton et al (2006) Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis. Proc.Natl.Acad.Sci.USA 103 17955.

Thompson and McNiven (2006) Discovery of a new 'dynasore'. Nat.Chem.Biol. 2 355. PMID: 16783339.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Dynasore, supplier, Non-competitive, dynamin, 1, 2, mitochondrial, Drp1, inhibitors, Mitosis, GTPases

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