R&D Systems Inc. Tocris Bioscience Boston Biochem

Suramin hexasodium salt

Cat. No. 1472

Suramin hexasodium salt C51H34N6Na6O23S6 [129-46-4]

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Chemical Name: 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt

Biological Activity

Non-selective P2 purinergic antagonist. Also blocks calmodulin binding to recognition sites and G protein coupling to G protein-coupled receptors. Increases open probability of ryanodine receptor (RyR) channels. Anticancer and antiviral agent.

Technical Data

M.Wt:
1429.15
Formula:
C51H34N6Na6O23S6
Solubility:
Soluble to 50 mM in water and to 10 mM in DMSO
Storage:
Store at RT
CAS No:
129-46-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Voogd et al (1993) Recent research on the biological activity of suramin. Pharmacol.Rev. 45 177. PMID: 8396782.

Beindl et al (1996) Inhibition of receptor/G protein coupling by suramin analogues. Mol.Pharmacol. 50 415. PMID: 8700151.

Charlton et al (1996) PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors. Br.J.Pharmacol. 118 704. PMID: 8762097.

Klinger et al (2001) Suramin and the suramin analogue NF307 discriminate among calmodulin-binding sites. Biochem.J. 355 827. PMID: 11311147.

Hill et al (2004) Functional regulation of the cardiac ryanodine receptor by suramin and calmodulin involves multiple binding sites. Mol.Pharmacol. 65 1258. PMID: 15102954.

If you know of a relevant citation for this product please let us know.

Keywords: Suramin hexasodium salt, supplier, Non-Selective, P2, antagonists, P2X, P2Y, Uncouples, G, proteins, from, receptors, heterotrimeric, purinoceptors

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