Suramin hexasodium salt

Cat. No. 1472

Suramin hexasodium salt C51H34N6Na6O23S6 [129-46-4]

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Chemical Name: 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt

Biological Activity

Non-selective P2 purinergic antagonist. Also blocks calmodulin binding to recognition sites and G protein coupling to G protein-coupled receptors. Increases open probability of ryanodine receptor (RyR) channels. Anticancer and antiviral agent.

Technical Data

Soluble to 50 mM in water and to 10 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Voogd et al (1993) Recent research on the biological activity of suramin. Pharmacol.Rev. 45 177. PMID: 8396782.

Beindl et al (1996) Inhibition of receptor/G protein coupling by suramin analogues. Mol.Pharmacol. 50 415. PMID: 8700151.

Charlton et al (1996) PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors. Br.J.Pharmacol. 118 704. PMID: 8762097.

Klinger et al (2001) Suramin and the suramin analogue NF307 discriminate among calmodulin-binding sites. Biochem.J. 355 827. PMID: 11311147.

Hill et al (2004) Functional regulation of the cardiac ryanodine receptor by suramin and calmodulin involves multiple binding sites. Mol.Pharmacol. 65 1258. PMID: 15102954.

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Keywords: Suramin hexasodium salt, supplier, Non-Selective, P2, antagonists, P2X, P2Y, Uncouples, G, proteins, from, receptors, heterotrimeric, purinoceptors, ryanodine, receptors, ion, channels, Purinergic (P2X) Receptor Antagonists

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