Cat. No. 1439
Chemical Name: Ammoniated ruthenium oxychloride
Biological ActivityBlocks Ca2+ uptake and release from mitochondria, and Ca2+ release from ryanodine-sensitive intracellular stores. Also blocks cell membrane-located capsaicin-activated cation channels (IC50 = 14 nM) and voltage-sensitive Ca2+ channels to inhibit neurotransmitter release.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Bernardi et al (1984) Pathway for uncoupler-induced calcium efflux in rat liver mitochondria: inhibition by ruthenium red. Biochemistry 23 1645. PMID: 6202317.
Amann and Maggi (1991) Ruthenium red as a capsaicin antagonist. Life Sci. 49 849. PMID: 1715010.
Szallasi and Blumberg (1999) Vanilloid (capsaicin) receptors and mechanisms. Pharmacol.Rev. 51 159. PMID: 10353985.
Xu et al (1999) Ruthenium red modifies the cardiac and skeletal muscle Ca2+ release channels (ryanodine receptors) by multiple mechanisms. J.Biol.Chem. 274 32680. PMID: 10551824.
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Keywords: Ruthenium Red, supplier, Inhibitors, ryanodine-sensitive, Ca2+, release, mitochondrial, reuptake, Blockers, capsaicin-activated, cation, channels, Non-Selective, Vanillioid, Receptors, VR1, TRPV, Transient, Receptor, Potential, CaV, P-Type, N-Type, voltage-gated, voltage-dependent, Tocris Bioscience, Voltage-gated Calcium Channel (CaV) Blockers