Ruthenium Red

Cat. No. 1439

Ruthenium Red H42N14O2Ru3Cl6 [11103-72-3]

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Chemical Name: Ammoniated ruthenium oxychloride

Biological Activity

Blocks Ca2+ uptake and release from mitochondria, and Ca2+ release from ryanodine-sensitive intracellular stores. Also blocks cell membrane-located capsaicin-activated cation channels (IC50 = 14 nM) and voltage-sensitive Ca2+ channels to inhibit neurotransmitter release.

Technical Data

Soluble to 10 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Bernardi et al (1984) Pathway for uncoupler-induced calcium efflux in rat liver mitochondria: inhibition by ruthenium red. Biochemistry 23 1645. PMID: 6202317.

Amann and Maggi (1991) Ruthenium red as a capsaicin antagonist. Life Sci. 49 849. PMID: 1715010.

Szallasi and Blumberg (1999) Vanilloid (capsaicin) receptors and mechanisms. Pharmacol.Rev. 51 159. PMID: 10353985.

Xu et al (1999) Ruthenium red modifies the cardiac and skeletal muscle Ca2+ release channels (ryanodine receptors) by multiple mechanisms. J.Biol.Chem. 274 32680. PMID: 10551824.

If you know of a relevant citation for this product please let us know.

View Related Products by Product Action

Keywords: Ruthenium Red, supplier, Inhibitors, ryanodine-sensitive, Ca2+, release, mitochondrial, reuptake, Blockers, capsaicin-activated, cation, channels, Non-Selective, Vanillioid, Receptors, VR1, TRPV, Transient, Receptor, Potential, CaV, P-Type, N-Type, voltage-gated, voltage-dependent, Voltage-gated Calcium Channel (CaV) Blockers

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