Cat. No. 1437
Chemical Name: O-(Octahydro-4,7-methano-1H-inden-5
Biological ActivitySelective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6.4 μM); antiviral and antitumor agent. Suppresses LPS- and IFNγ-induced NO production (IC50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Tschiakowsky et al (1994) Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan-9-yl-xanthogenate (D609). Br.J.Pharmacol. 113 664. PMID: 7532078.
Amtmann (1996) The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C. Drugs Exp.Clin.Res. 22 287. PMID: 9034754.
Li et al (1998) Phosphatidylcholine-specific phospholipase C regulates glutamate-induced nerve cell death. Proc.Natl.Acad.Sci.U.S.A. 95 7748. PMID: 9636222.
Zhou et al (2001) D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent antioxidant. J.Pharmacol.Exp.Ther. 298 103. PMID: 11408530.
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Keywords: D609, supplier, Selective, PC-PLC, inhibitors, Phospholipases, C, Esterases