Cat. No. 1437
Chemical Name: O-(Octahydro-4,7-methano-1H-inden-5
Biological ActivitySelective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6.4 μM); antiviral and antitumor agent. Suppresses LPS- and IFNγ-induced NO production (IC50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Tschiakowsky et al (1994) Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan-9-yl-xanthogenate (D609). Br.J.Pharmacol. 113 664. PMID: 7532078.
Amtmann (1996) The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C. Drugs Exp.Clin.Res. 22 287. PMID: 9034754.
Li et al (1998) Phosphatidylcholine-specific phospholipase C regulates glutamate-induced nerve cell death. Proc.Natl.Acad.Sci.U.S.A. 95 7748. PMID: 9636222.
Zhou et al (2001) D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent antioxidant. J.Pharmacol.Exp.Ther. 298 103. PMID: 11408530.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: D609, supplier, Selective, PC-PLC, inhibitors, Phospholipases, C, Esterases
Find multiple products by catalog number
New Products in this Area
Highly selective and potent monoacylglycerol lipase (MAGL) inhibitorPF 8380
Potent autotaxin inhibitorAPY 29
Inhibits IRE1α autophosphorylation; activates IRE1α endoribonuclease activityJW 642
Monoacylglycerol (MAGL) inhibitorML 298 hydrochloride
Selective PLD2 inhibitor
Meet your representative
July 15, 2014