R&D Systems Inc. Tocris Bioscience Boston Biochem

D609

Cat. No. 1437

D609 C11H15OS2K [83373-60-8]

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Chemical Name: O-(Octahydro-4,7-methano-1H-inden-5-yl) carbonopotassium dithioate

Biological Activity

Selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6.4 μM); antiviral and antitumor agent. Suppresses LPS- and IFNγ-induced NO production (IC50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo.

Technical Data

M.Wt:
266.46
Formula:
C11H15OS2K
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
83373-60-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Tschiakowsky et al (1994) Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan-9-yl-xanthogenate (D609). Br.J.Pharmacol. 113 664. PMID: 7532078.

Amtmann (1996) The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C. Drugs Exp.Clin.Res. 22 287. PMID: 9034754.

Li et al (1998) Phosphatidylcholine-specific phospholipase C regulates glutamate-induced nerve cell death. Proc.Natl.Acad.Sci.U.S.A. 95 7748. PMID: 9636222.

Zhou et al (2001) D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent antioxidant. J.Pharmacol.Exp.Ther. 298 103. PMID: 11408530.

If you know of a relevant citation for this product please let us know.

Keywords: D609, supplier, Selective, PC-PLC, inhibitors, Phospholipases, C, Esterases

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