Ro 0437626

Cat No. 2188

Ro 0437626 C27H35N5O4S [134362-79-1]

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Chemical Name: N-[(1R)-2-[[(1S,2R,3S)-1-(Cyclohexylmethyl)-3-cycloprop yl-2,3-dihydroxypropyl]amino]-2-oxo-1-(4-thiazolylmethy l)ethyl]-1H-benzimidazole-2-carboxamide

Biological Activity

Selective P2X1 purinergic receptor antagonist (IC50 = 3 μM) that displays > 30-fold selectivity over P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM).

Technical Data

M.Wt:
525.66
Formula:
C27H35N5O4S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
[134362-79-1]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch
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Material Safety Data Sheet: View current batch
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References

Jaime-Figueroa et al (2005) Discovery and synthesis of a novel and selective drug-like P2X1 antagonist. Bioorg.Med.Chem.Lett. 15 3292. King et al (2004) Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetized rats. Br.J.Pharmacol. 142 519. Ford et al (2006) Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br.J.Pharmacol. 147 S132.

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