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SB 203580

Cat. No. 1202

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Chemical Name: 4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine

Biological Activity

Selective inhibitor of p38 mitogen-activated protein kinase (IC₅₀ values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK-3β and PKBα. Shown to inhibit interleukin-2-induced T-cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase. Enhances clonal growth of skin epithelial progenitor cells; stimulates neural stem cell (NSC) proliferation. Part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™. Water-soluble salt SB 203580 hydrochloride (Cat. No. 1402) also available.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M.Wt:

377.44

Formula:

C₂₁H₁₆FN₃OS

Solubility:

Soluble to 25 mM in DMSO and to 100 mM in 1eq. HCl

Purity:

>98 %

Storage:

Desiccate at +4°C

CAS No:

152121-47-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Other Information

Water-soluble Salt Available

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Saklatvala et al (1996) Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen on a thromboxane analogue. J.Biol.Chem. 271 6586. PMID: 8636072.

Borsch-Haubold et al (1998) Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. J.Biol.Chem. 273 28766. PMID: 9786874.

Davies et al (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 351 95. PMID: 10998351.

Sato et al (2008) Inhibitors of p38 mitogen-activated protein kinase enhance proliferation of mouse neural stem cells. J.Neurosci.Res. 86 2179. PMID: 18338804.

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Keywords: SB 203580, supplier, Selective, inhibitors, p38, MAPK, Mitogen-Activated, Protein, Kinases, Signaling, Signalling, SB203580, GlaxoSmithKline, GSK