Cat. No. 2177
Biological ActivityHighly selective NPY Y1 receptor antagonist. Ki values are 25.7, 1420, 2403 and 7100 nM at Y1, Y2, Y4 and Y5 receptors respectively. Devoid of agonist activity at Y4 receptors.
Licensing InformationSold under license
(Modifications: Tyr-9 = Tyr-OMe)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Balasubramaniam et al (2001) Highly selective and potent neuropeptide Y (NPY) Y1 receptor antagonists based on [Pro30, Tyr32, Leu34]NPY(28-36)-NH2 (BW1911U90). J.Med.Chem. 44 1479. PMID: 11334558.
Jois and Balasubramaniam (2003) Conformation of neuropeptide Y receptor antagonists: structural implications in receptor selectivity. Peptides 24 1035. PMID: 14499282.
Jois et al (2006) Modeling of neuropeptide receptors Y1, Y4, Y5, and docking studies with neuropeptide antagonist. J.Biomol.Struct.Dyn. 23 497. PMID: 16494499.
If you know of a relevant citation for this product please let us know.
Keywords: BVD 10, supplier, selective, Y1, antagonists, devoid, Y4, agonists, activity, Neuropeptide, Y, Receptors, NPY, BVD10, neuropeptides
Find multiple products by catalog number
New Products in this Area
Potent parathyroid hormone (PTH) receptor agonistObestatin (human)
Endogenous reported anorexigenic peptideTC NTR1 17
Selective non-peptide NTS1 agonistML 354
Selective PAR4 antagonistGW 438014A
NPY Y5 receptor antagonistTC-FPR 43
Potent FPR2 agonistTC-G 1003
High affinity somatostatin sst2 receptor agonist
June 24 - 27, 2015
Booth Number: B11:25