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BVD 10

Cat. No. 2177

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Biological Activity

Highly selective NPY Y₁ receptor antagonist. K_i values are 25.7, 1420, 2403 and 7100 nM at Y₁, Y₂, Y₄ and Y₅ receptors respectively. Devoid of agonist activity at Y₄ receptors.

Licensing Information

Sold under license

Technical Data

M.Wt:

1221.46

Formula:

C₅₈H₉₂N₁₆O₁₃

Sequence:

INPIYRLRY

(Modifications: Tyr-9 = Tyr-OMe)

Solubility:

Soluble to 1 mg/ml in 20% acetonitrile / water

Storage:

Desiccate at -20°C

CAS No:

262418-00-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Balasubramaniam et al (2001) Highly selective and potent neuropeptide Y (NPY) Y1 receptor antagonists based on [Pro³⁰, Tyr³², Leu³⁴]NPY(28-36)-NH₂ (BW1911U90). J.Med.Chem. 44 1479. PMID: 11334558.

Jois and Balasubramaniam (2003) Conformation of neuropeptide Y receptor antagonists: structural implications in receptor selectivity. Peptides 24 1035. PMID: 14499282.

Jois et al (2006) Modeling of neuropeptide receptors Y1, Y4, Y5, and docking studies with neuropeptide antagonist. J.Biomol.Struct.Dyn. 23 497. PMID: 16494499.

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Keywords: BVD 10, supplier, selective, Y1, antagonists, devoid, Y4, agonists, activity, Neuropeptide, Y, Receptors, NPY, BVD10, neuropeptides

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