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PACAP 1-27

Cat. No. 1183

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Alternative Name: Pituitary Adenylate Cyclase-Activating Polypeptide 1-27

Biological Activity

Endogenous neuropeptide showing considerable homology with vasoactive intestinal peptide (VIP). Potently stimulates adenylyl cyclase.

Technical Data

M.Wt:

3147.6

Formula:

C₁₄₂H₂₂₄N₄₀O₃₉S

Sequence:

HSDGIFTDSYSRYRKQMAVKKYLAAVL

(Modifications: Leu-27 = C-terminal amide)

Solubility:

Soluble to 1 mg/ml in water

Storage:

Desiccate at -20°C

CAS No:

127317-03-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Rawlings et al (1994) Pituitary adenylate cyclase-activating polypeptide increase [Ca²⁺]i in rat gonadotrophs through an inositol trisphosphate-dependent mechanism. J.Biol.Chem. 269 5680. PMID: 7907085.

Hirose et al (1997) Pituitary adenylate cyclase-activating polypeptide-27 causes a biphasic chronotropic effect and atrial fibrillation in autonomically decentralized, anaesthetized dogs. J.Pharmacol.Exp.Ther. 283 478. PMID: 9353360.

Michel et al (1998) XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol.Rev. 50 143. PMID: 9549761.

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Keywords: PACAP 1-27, supplier, Potently, stimulates, adenylyl, cyclases, stimulator, adenylate, Inositol, cAMP, Signaling, Signalling, Pituitary, Adenylate, Activating, Peptide, Receptors, PAC1, PACAP127

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7-TM Receptor Signaling

Written by T. Kenakin et al

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy