Cat. No. 2157
Chemical Name: [[(1R,2R,3S,4R,5S)-4-[6-Amino-2-(me
Biological ActivityHighly potent, selective P2Y1 receptor agonist (EC50 = 0.4 nM). Displays no activity at P2Y12 receptors and only very low agonist activity at P2Y13 receptors (at concentrations up to 1 μM). Increases the upregulation of NTPDase1 by ATPγS.
Licensing InformationSold under license from the NIH, US Patent 10/169975
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Ravi et al (2002) Adenine nucleotide analogues locked in a northern methanocarba conformation: enhanced stability and potency as P2Y1 receptor agonists. J.Med.Chem. 45 2090. PMID: 11985476.
Chhatriwala et al (2004) Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog. J.Pharmacol.Exp.Ther. 311 1038. PMID: 15345752.
Lu et al (2007) Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells. J.Pharmacol.Exp.Ther. 323 157. PMID: 17626796.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: MRS 2365, supplier, potent, selective, P2Y1, agonists, Receptors, Purinergic, purinoceptors, MRS2365
Find multiple products by catalog number
New Products in this Area
Selective FFA1 (GPR40) agonist(±)-NBI 74330
Potent and selective CXCR3 antagonistPurmorphamine
Smo receptor agonistCTCE 9908
CXCR4 antagonist; antitumorVUF 11207 fumarate
Potent CXCR7 agonistTC-G 1006
Potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonistDMNPE-caged ATP diammonium salt
Caged ATPMK 1903
Potent and selective GPR109A (HCA2) agonistM 25
Potent Smoothened (Smo) receptor antagonistKi 16425
LPA1 and LPA3 receptor antagonistCYM 50358 hydrochloride
Potent and selective S1P4 antagonist(±)-AMG 487
CXCR3 antagonist; inhibits cell migration and metastasisGW 627368
Selective EP4 receptor competitive antagonistLUF 6283
HCA2 (GPR109A) partial agonistNS 304
Selective prostacyclin IP1 receptor agonist
May 2-6, 2014
Booth Number: 523