R&D Systems Inc. Tocris Bioscience Boston Biochem

MRS 2365

Cat. No. 2157

MRS 2365 C13H16N5O9P2SNa3 [436847-09-5]

Price and Availability

For MRS 2365 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: [[(1R,2R,3S,4R,5S)-4-[6-Amino-2-(methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl] diphosphoric acid mono ester trisodium salt

Biological Activity

Highly potent, selective P2Y1 receptor agonist (EC50 = 0.4 nM). Displays no activity at P2Y12 receptors and only very low agonist activity at P2Y13 receptors (at concentrations up to 1 μM). Increases the upregulation of NTPDase1 by ATPγS.

Licensing Information

Sold under license from the NIH, US Patent 10/169975

Technical Data

M.Wt:
549.28
Formula:
C13H16N5O9P2SNa3
Solubility:
Soluble in water (supplied pre-dissolved at a concentration of 10mM)
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
436847-09-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Ravi et al (2002) Adenine nucleotide analogues locked in a northern methanocarba conformation: enhanced stability and potency as P2Y1 receptor agonists. J.Med.Chem. 45 2090. PMID: 11985476.

Chhatriwala et al (2004) Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog. J.Pharmacol.Exp.Ther. 311 1038. PMID: 15345752.

Lu et al (2007) Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells. J.Pharmacol.Exp.Ther. 323 157. PMID: 17626796.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: MRS 2365, supplier, potent, selective, P2Y1, agonists, Receptors, Purinergic, purinoceptors, MRS2365

Quick Order

Find multiple products by catalog number

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Guide

Highlights over 250 products for cardiovascular research. Request a copy or view PDF today.

divider line

P2 Receptors Review

Purinergic Receptor Review

Written by Kenneth Jacobson, an expert in the field. Request a copy or view PDF today.

divider line

Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Poster

'Regulation of Vascular Reactivity by G-protein-coupled Receptors' summarizes the key GPCRs regulating vascular reactivity.

divider line

7-TM Receptor Signaling

Written by T. Kenakin et al

7-TM Poster

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy

divider line

New Product Guide

NPG

Highlights over 130 new products added in the second half of 2013. Request a copy or view PDF today.

divider line

New Products in this Area

Prosaptide TX14(A)

Potent GPR37 and GPR37L1 agonist

AS 2034178

Selective FFA1 (GPR40) agonist

(±)-NBI 74330

Potent and selective CXCR3 antagonist

Purmorphamine

Smo receptor agonist

CTCE 9908

CXCR4 antagonist; antitumor

VUF 11207 fumarate

Potent CXCR7 agonist

TC-G 1006

Potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonist

DMNPE-caged ATP diammonium salt

Caged ATP

MK 1903

Potent and selective GPR109A (HCA2) agonist

M 25

Potent Smoothened (Smo) receptor antagonist

Sign-up for new product e-alerts
divider line

Bio-Techne Events

Purines 2014

Purines 2014

July 23 - 27, 2014

Bonn University, Germany