Cat. No. 2900
Chemical Name: (βR)-β-[[[(1S)-1-[[[(1S)-2-Methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-[1,1'-biphenyl]-4-hexanoic acid
Biological ActivityHighly selective MMP-3 and MMP-12 inhibitor (IC50 values are 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 and 66.9 μM at MMP 3, 12, 8, 13, 7, 9, 2 and 14 respectively.) Inhibits fibronectin cleavage (IC50 = 320 nM) and has little effect on keratinocyte migration in vitro. Substantially inhibits MMP-3 in an ex vivo model of chronic dermal ulcers.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Fray et al (2003) A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic duodenal ulcers. J.Med.Chem. 46 3514. PMID: 12877590.
Whitlock et al (2007) A novel series of highly selective inhibitors of MMP-3. Bioorg.Med.Chem.Letts. 17 6750.
Matthews et al (2008) Formulation, stability and thermal analysis of lypophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant. Int.J.Pharmaceutics 356 110.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: UK 370106, supplier, selective, MMP-3, MMP-12, inhibitors, Matrixins, Matrix, Metalloproteinase, MMP, Metalloprotease, Proteinases, Proteases, UK370106
Find multiple products by catalog number
New Products in this Area
Dipeptidyl peptidase II (DPP-II) inhibitorVialinin A
Inhibitor of USP4 and USP5/IsoTMI 2 (MALT1 inhibitor)
MALT1 inhibitorNSC 687852
Inhibitor UCHL5 and USP14GI 254023X
Selective ADAM10 metalloprotease inhibitorGM 6001
Broad-spectrum MMP inhibitorNSC 405020
Inhibitor of MT1-MMP; antitumor
Win a Kindle
December 17 - 19, 2013