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Nicorandil

Cat. No. 2147

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Chemical Name: N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide

Biological Activity

K_ir6 (K_ATP) channel opener and NO donor; antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing K_ir6 channels (EC₅₀ values are 10 and > 500 μM respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning.

Technical Data

M.Wt:

211.18

Formula:

C₈H₉N₃O₄

Solubility:

Soluble to 20 mM in water

Storage:

Desiccate at +4°C

CAS No:

65141-46-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Shindo et al (1998) SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K⁺ channels by pinacidil and nicorandil. Br.J.Pharmacol. 124 985. PMID: 9692785.

Gomma et al (2001) Potassium channel openers in myocardial ischaemia: therapeutic potential of nicorandil. Drugs 61 1705. PMID: 11693460.

Horinaka et al (2001) Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat. J.Cardiovasc.Pharmacol. 38 200. PMID: 11483869.

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Keywords: Nicorandil, supplier, KATP, channel, openers, NO, donor, Potassium, KIR, Channels, Inward, Rectifier, K+, ROS, Donors, Precursors, Nitric, Oxide, Signaling, Signalling, Kir6