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MRS 2578

Cat. No. 2146

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Chemical Name: N,N''-1,4-Butanediylbis[N'-(3-isothiocyanatophenyl)thiourea

Biological Activity

Selective antagonist of P2Y₆ nucleotide receptors; IC₅₀ values are 37 and 98 nM at human and rat P2Y₆ receptors respectively. Displays no activity at P2Y₁, P2Y₂, P2Y₄ and P2Y₁₁ receptors (IC₅₀ > 10 μM). Inhibits agonist-induced cardiomyocyte contraction and UDP-induced phagocytosis.

Technical Data

M.Wt:

472.66

Formula:

C₂₀H₂₀N₆S₄

Solubility:

Soluble to 50 mM in DMSO

Purity:

>95 %

Storage:

Desiccate at -20°C

CAS No:

711019-86-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Mamedova et al (2004) Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y₆ nucleotide receptors. Biochem.Pharmacol. 67 1763. PMID: 15081875.

Koizumi et al (2007) UDP acting at P2Y₆ receptors is a mediator of microglial phagocytosis. Nature 446 1091. PMID: 17410128.

Kukulski et al (2007) Extracellular nucleotides mediate LPS-induced neutrophil migration in vitro and in vivo. J.Leukoc.Biol. 81 1269. PMID: 17322022.

If you know of a relevant citation for this product please let us know.

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