R&D Systems Inc. Tocris Bioscience Boston Biochem

DuP 697

Cat. No. 1430

DuP 697 C17H12BrFO2S2 [88149-94-4]

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Chemical Name: 5-Bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-thiophene

Biological Activity

Potent and selective inhibitor of cyclooxygenase-2 (IC50 values are 10 and 800 nM for COX-2 and COX-1 respectively). Inhibits prostaglandin synthesis and is anti-inflammatory in vivo. Orally active.

Technical Data

M.Wt:
411.3
Formula:
C17H12BrFO2S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
88149-94-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Gans et al (1990) Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor. J.Pharmacol.Exp.Ther. 254 180. PMID: 2366180.

Gierse et al (1995) Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem.J. 305 479. PMID: 7832763.

Rossoni et al (2002) Inhibition of cyclo-oxygenase-2 exacerbates ischaemia-induced acute myocardial dysfunction in the rabbit. Br.J.Pharmacol. 135 1540. PMID: 11906968.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: DuP 697, supplier, Cyclooxygenase-2, COX-2, inhibitors, Cyclooxygenase, Oxygenases, Oxidases, DuP697

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