DuP 697

Cat. No. 1430

DuP 697 C17H12BrFO2S2 [88149-94-4]

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Chemical Name: 5-Bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-thiophene

Biological Activity

Potent and selective inhibitor of cyclooxygenase-2 (IC50 values are 10 and 800 nM for COX-2 and COX-1 respectively). Inhibits prostaglandin synthesis and is anti-inflammatory in vivo. Orally active.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Gans et al (1990) Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor. J.Pharmacol.Exp.Ther. 254 180. PMID: 2366180.

Gierse et al (1995) Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem.J. 305 479. PMID: 7832763.

Rossoni et al (2002) Inhibition of cyclo-oxygenase-2 exacerbates ischaemia-induced acute myocardial dysfunction in the rabbit. Br.J.Pharmacol. 135 1540. PMID: 11906968.

If you know of a relevant citation for this product please let us know.

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Keywords: DuP 697, supplier, Cyclooxygenase-2, COX-2, inhibitors, Cyclooxygenase, Oxygenases, Oxidases, DuP697, Cyclooxygenase Inhibitors

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