2,3-DCPE hydrochloride

Cat. No. 2137

2,3-DCPE hydrochloride C11H15Cl2NO2.HCl [1009555-55-8]

Price and Availability

For 2,3-DCPE hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 2-[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol hydrochloride

Biological Activity

Selectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro. IC50 values are 0.89 and 12.6 μM for LoVo human colon cancer cell line and normal human fibroblasts respectively. Induces p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways.

Technical Data

M.Wt:
300.61
Formula:
C11H15Cl2NO2.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
1009555-55-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Wu et al (2004) Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol. Cancer Res. 64 1110. PMID: 14871845.

Zhu et al (2004) Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol in correlation with activation of ERK. Oncogene 23 4984. PMID: 15122344.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: 2,3-DCPE hydrochloride, supplier, Selectively, induces, cancer, cell, apoptosis, Downregulates, Bcl-XL, protein, expression, Apoptosis, Inducer, Tocris Bioscience, Apoptosis Inducers

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Programmed Cell Death

Written by Bram van Raam and Guy Salvesen

Programmed Cell Death Life Science Poster

A summary of the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation. Request copy or view PDF today.

divider line

Apoptosis Pathway

Apoptosis Signaling Pathway

Apoptosis is a mechanism of cell death which occurs after sufficient cellular damage. View pathway or download PDF today.

divider line

AAI 2016

Win a $1,000 travel grant

AAI Travel Grant

Bio-Techne is offering 10 travel grants of $1,000 for AAI 2016.