Cat. No. 2137
Chemical Name: 2-[[3-(2,3-Dichlorophenoxy)propyl]a
Biological ActivitySelectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro. IC50 values are 0.89 and 12.6 μM for LoVo human colon cancer cell line and normal human fibroblasts respectively. Induces p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Wu et al (2004) Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol. Cancer Res. 64 1110. PMID: 14871845.
Zhu et al (2004) Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol in correlation with activation of ERK. Oncogene 23 4984. PMID: 15122344.
If you know of a relevant citation for this product please let us know.
Keywords: 2,3-DCPE hydrochloride, supplier, Selectively, induces, cancer, cell, apoptosis, Downregulates, Bcl-XL, protein, expression, Apoptosis, Inducer
Find multiple products by catalog number
New Products in this Area
Deoxyadenosine analog; pro-apoptoticUC 112
IAP and XIAP inhibitor; antitumorAZD 5582 dihydrochloride
Dimeric Smac mimetic; potent IAP inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.