Cat. No. 2085
Chemical Name: 3-Cyclohexyl-N-[(9H-fluoren-9-ylmet
Biological ActivityNovel non-peptide galanin GAL1 and GAL2 receptor agonist (Ki values are 11.7 and 34.1 μM respectively). Stimulates insulin release in isolated pancreatic islets from normal and diabetic rats. Systemically active in vivo; displays anticonvulsant activity following i.p. administration in mice. Central and peripheral administration also transiently inhibits food intake in rats and mice.
(Modifications: Ala-1 = Fmoc-β-cyclohexyl-Ala, Lys-2 = Lys-(4-methyl-2-oxo-2H-1-benzo
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Saar et al (2002) Anticonvulsant activity of a nonpeptide galanin receptor agonist Proc.Natl.Acad.Sci.USA 99 7136. PMID: 12011470.
Abramov et al (2004) Regulation of feeding by galnon. Neuropeptides 38 55. PMID: 15003717.
Lu et al (2005) A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc.Natl.Acad.Sci. 102 874. PMID: 15647369.
Quynh et al (2005) Effects of galnon, a non-peptide galanin-receptor agonist, on insulin release from rat pancreatic islets. Biochem.Biophys.Res.Comm. 328 213. PMID: 15670772.
If you know of a relevant citation for this product please let us know.
Keywords: Galnon, supplier, Selective, non-peptide, GAL1, GalR1, agonists, Receptors, Galanin
Find multiple products by catalog number
New Products in this Area
Endogenous ligand for canine kisspeptin receptorMK 0677
High affinity ghrelin receptor agonistUrantide
Selective and competitive urotensin II antagonistML 154
Potent neuropeptide S receptor (NPSR) antagonistTC OT 39
Potent non-peptide oxytocin receptor partial agonist; also V1a receptor antagonistTolvaptan
Potent and selective vasopressin V2 receptor antagonist; renoprotective and orally active
One Day Symposium
March 17, 2015