R&D Systems Inc. Tocris Bioscience Boston Biochem

PHM 27 (human)

Cat. No. 2080

PHM 27 (human) His-Ala-Asp-Gly-Val-Phe-Thr-Ser-Asp-Phe-Ser-Lys-Leu-Leu-Gly-Gln-Leu-Ser-Ala-Lys-Lys-Tyr-Leu-Glu-Ser-Leu-Met-NH2

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Alternative Names: Peptide histidine methionine 27 (human), Human PHI 27

Biological Activity

Endogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC50 = 11 nM). Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic β-islets display enhanced glucose-induced insulin secretion.

Technical Data

M.Wt:
2985.44
Formula:
C135H214N34O40S
Sequence:
HADGVFTSDFSKLLGQLSAKKYLESLM

(Modifications: Met-27 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in 5% acetonitrile / water
Storage:
Desiccate at -20°C
CAS No:
118025-43-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Itoh et al (1983) Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27. Nature 304 547. PMID: 6571696.

Kato et al (1994) Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic β cells. J.Biol.Chem. 269 21223. PMID: 8063743.

Ma et al (2004) Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor. Biochem.Pharmacol. 67 1279. PMID: 15013843.

If you know of a relevant citation for this product please let us know.

Keywords: PHM 27 (human), supplier, Potent, calcitonin, receptor, agonists, endogenous, human, VIP, prepro-VIP, analogue, porcine, PHI27, Receptors, Vasoactive, intestinal, peptide, PHM27, (human), Peptide, histidine, methionine27

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