PHM 27 (human)
Cat. No. 2080
Alternative Names: Peptide histidine methionine 27 (human), Human PHI 27
Biological ActivityEndogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC50 = 11 nM). Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic β-islets display enhanced glucose-induced insulin secretion.
(Modifications: Met-27 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Itoh et al (1983) Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27. Nature 304 547. PMID: 6571696.
Kato et al (1994) Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic β cells. J.Biol.Chem. 269 21223. PMID: 8063743.
Ma et al (2004) Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor. Biochem.Pharmacol. 67 1279. PMID: 15013843.
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Keywords: PHM 27 (human), supplier, Potent, calcitonin, receptor, agonists, endogenous, human, VIP, prepro-VIP, analogue, porcine, PHI27, Receptors, Vasoactive, intestinal, peptide, PHM27, (human), Peptide, histidine, methionine27
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