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cis-ACPD

Cat. No. 0186

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Chemical Name: (±)-1-Aminocyclopentane-cis-1,3-dicarboxylic acid

Biological Activity

1:1 mixture of (1R,3R)- and (1S,3S)-ACPD. Potent NMDA receptor agonist and selective group II mGluR agonist (EC₅₀ values are 13, 50, >300 and >300 μM at mGluR₂, mGluR₄, mGluR₁ and mGluR₅ respectively). Exhibits proconvulsant activity in vivo. (±)-trans-ACPD (Cat. No. 0187) and (1S,3R)-ACPD (Cat. No. 0284) also available.

Technical Data

M.Wt:

173.17

Formula:

C₇H₁₁NO₄

Solubility:

Soluble to 100 mM in 1eq. NaOH

Storage:

Store at RT

CAS No:

477331-06-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Other Information

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Schoepp et al (1991) In vitro and in vivo pharmacology of trans- and cis-(±)-1-amino-1,3-cyclopentanedicarboxylic acid: Dissociation of metabotropic and ionotropic excitatory amino acid receptor effects. J.Neurochem. 56 1789. PMID: 1849553.

Sunter et al (1991) Actions of the four isomers of 1-aminocyclopentane-1,3-dicarboxylate (ACPD) in the hemisected spinal cord of the neonatal rat. Br.J.Pharmacol. 104 337P.

Conti et al (2002) Synthesis and pharmacology of 3-hydroxy-Δ²-isoxazoline-cyclopentane analogues of glutamic acid. Farmaco 57 889. PMID: 12484537.

If you know of a relevant citation for this product please let us know.

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