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Carvedilol

Cat No. 2685

Price and Availability

Alternative Name: BM 14190

Chemical Name: 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]am ino]-2-propanol

Biological Activity

Potent β-adrenoceptor and α₁-adrenoceptor antagonist (K_i values are 0.81, 0.96 and 2.2 nM for β₁-, β₂- and α₁-adrenoceptors respectively) that displays antihypertensive and peripheral vasodilatory activity. Blocks cardiac inward-rectifier K⁺ (K_IR) channels, voltage-dependent Ca²⁺ channels and exhibits antioxidant properties at higher concentrations.

Technical Data

M.Wt:

406.47

Formula:

C₂₄H₂₆N₂O₄

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in Ethanol

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

[72956-09-3]

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Ohlstein et al (1993) Carvedilol, a cardiovascular drug, prevents vascular smooth muscle cell proliferation, migration, and neointimal formation following vascular injury. Proc.Natl.Acad.Sci.USA. 90 6189. Ponicke et al (2002) Differential effects of bucindolol and carvedilol on noradrenaline-induced hypertonic response in ventricular cardiomyocytes of adult rats. J.Pharmacol.Exp.Ther. 301 71. Kikuta et al (2006) Carvedilol blocks cardiac K_ATP and K_G but not I_K1 channels by acting at the bundle-crossing region. Eur.J.Pharmacol. 529 47.