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Zolpidem

Cat No. 0655

Price and Availability

Special Conditions

This product is a Controlled Substance and may have associated conditions of supply.

Chemical Name: N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine -3-acetamide

Biological Activity

Benzodiazepine agonist with high selectivity for α1-subunit-containing GABA_A receptors (BZ/ω₁ site) and very high intrinsic activity. K_i values are 20, 400 and ≥ 5000 nM for α1-, α 2-/α3-, and α5-containing GABA_A receptors respectively. Hypnotic that does not induce physical dependence.

Technical Data

M.Wt:

307.39

Formula:

C₁₉H₂₁N₃O

Solubility:

Soluble to 100 mM in 1eq. NaOH and to 100 mM in Ethanol

Purity:

>99 %

Storage:

Store at RT

CAS No:

[82626-48-0]

Resources

Certificate of Analysis / MSDS

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References

Arbilla et al (1986) High affinity [³H]zolpidem binding in the rat brain: an imidazopyridine with agonist properties at central benzodiazepine receptors. Eur.J.Pharmacol. 130 257. Depoortere et al (1986) Zolpidem, a novel nonbenzodiazepine hypnotic. 1. Neuropharmacological and behavioural effects. J.Pharmacol.Exp.Ther. 237 649. Perrault et al (1992) Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zolpidem. J.Pharmacol.Exp.Ther. 263 298. Crestani et al (2000) Mechanism of action of the hypnotic zolpidem in vivo. Br.J.Pharmacol. 131 1251.