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Sibutramine hydrochloride
68199-2290-2 CIV

Cat No. 2290

Sibutramine hydrochloride C17H26NCl.HCl [84485-00-7]

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Special Conditions

This product is a Controlled Substance and may have associated conditions of supply.

Alternative Name: BTS 54-524

Chemical Name: 1-(4-Chlorophenyl)-N,N-dimethyl-a-(2-methylpropyl)cyclob utanemethanamine hydrochloride

Biological Activity

5-HT and noradrenalin re-uptake inhibitor (SNRI). Produces weight loss in rats via inhibition of food intake and increased energy expenditure. Antidepressant.

Technical Data

M.Wt:

316.31

Formula:

C₁₇H₂₆NCl.HCl

Solubility:

Soluble to 5 mM in Water and to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at RT

CAS No:

[84485-00-7]

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

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Material Safety Data Sheet: View current batch

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References

Buckett et al (1988) The pharmacology of sibutramine hydrochloride (BTS 54524), a new antidepressant which induces rapid noradrenergic down-regulation. Prog.Neuro-Psychopharm.Biol.Psychiat. 12 575. Jackson et al (1997) Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat. Br.J.Pharmacol. 121 1758. Gundlah et al (1997) In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutramine is a reuptake inhibitor. J.Pharmacol.Exp.Ther. 283 581.