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Home »
Pharmacology » 7-TM Receptors » Histamine Receptors » Histamine H1 Receptors » Doxepin hydrochloride
Doxepin hydrochloride
Cat No. 0508
Price and Availability
Chemical Name: 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]o xepin hydrochloride
Biological Activity
Highly potent H1 histamine receptor antagonist (Kd = 310 pM) and tricyclic antidepressant. Also binds to the H4 histamine receptor (pKi = 6.79).Technical Data
M.Wt:315.84
Formula:C19H21NO.HCl
Solubility:Soluble to 100 mM in Water
Storage:Store at RT
CAS No:[1668-19-5]
Resources
Certificate of Analysis / MSDS
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References
Merck Index 12 3492. Tran et al (1981) [3H]Doxepin interactions with histamine H1-receptors and other sites in guinea pig brain homogenates. Eur.J.Pharmacol. 70 501. Lurchins (1983) Review of clinical and animal studies comparing the cardiovascular effects of doxepin and other tricyclic antidepressants. Am.J.Psychiatry 140 1006. Nguyen et al (2001) Discovery of a novel member of the histamine receptor family. Mol.Pharmacol. 59 427.Keywords: Doxepin hydrochloride, H1, histamine, H4
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