Doxepin hydrochloride

Cat No. 0508

Doxepin hydrochloride
 C19H21NO.HCl [1668-19-5]

Price and Availability

Qty
1 g / $39 In stock
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Chemical Name: 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]o xepin hydrochloride

Biological Activity

Highly potent H1 histamine receptor antagonist (Kd = 310 pM) and tricyclic antidepressant. Also binds to the H4 histamine receptor (pKi = 6.79).

Technical Data

M.Wt:
315.84
Formula:
C19H21NO.HCl
Solubility:
Soluble to 100 mM in Water
Storage:
Store at RT
CAS No:
[1668-19-5]

Certificate of Analysis / MSDS

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References

Merck Index 12 3492. Tran et al (1981) [3H]Doxepin interactions with histamine H1-receptors and other sites in guinea pig brain homogenates. Eur.J.Pharmacol. 70 501. Lurchins (1983) Review of clinical and animal studies comparing the cardiovascular effects of doxepin and other tricyclic antidepressants. Am.J.Psychiatry 140 1006. Nguyen et al (2001) Discovery of a novel member of the histamine receptor family. Mol.Pharmacol. 59 427.

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Keywords: Doxepin hydrochloride, H1, histamine, H4

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