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DMAB-anabaseine dihydrochloride

Cat No. 2241

Price and Availability

Chemical Name: 4-[(5,6-Dihydro[2,3'-bipyridin]-3(4H)-ylidene)methyl]-N, N-dimethylbenzenamine dihydrochloride

Biological Activity

Partial agonist at α7-containing neuronal nicotinic receptors and antagonist at α4β2 and other nicotinic receptors. Displays specific cognition-enhancing effects; improves long-term memory in rats.

Technical Data

M.Wt:

364.32

Formula:

C₁₉H₂₁N₃.2HCl

Solubility:

Soluble to 100 mM in Water

Purity:

>98 %

Storage:

Desiccate at -20°C

CAS No:

[32013-69-7]

Resources

Certificate of Analysis / MSDS

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References

Arendash et al (1995) Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21. Brain Res. 674 252. Kem et al (1997) Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. J.Pharmacol.Exp.Ther. 283 979. Stevens et al (1998) Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice. Psychopharmacology 136 320.