New Products

Cat.No.

Product Name / Activity

Added

Inhibitor of farnesyl diphosphate synthase (FPPS) and osteoclast-mediated bone resorption

Caged (S)-AMPA

Selective mGlu₁ antagonist

Sodium salt of kynurenic acid (Cat. No. 0223)

Sodium salt of (RS)-MCPG (Cat. No. 0336)

Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor

Neuroprotective peptide; protects against β-amyloid neurotoxicity

Prohormone of calcitriol (Cat.No. 2551). Major circulating form of vitamin D

CFTR mutants potentiator

α5-selective GABA_A inverse agonist

GLI1 antagonist; inhibits Hh signaling

Potent γ-secretase inhibitor

SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) inhibitor

p38 MAPK inhibitor

Selective D₄ receptor ligand

Selective B₂ antagonist; analog of HOE 140 (Cat.No. 3014).

Potent fatty acid synthase inhibitor; proapoptotic

Activator of BK_Ca channels

Positive allosteric modulator of mGlu₂

Inhibitor of SOCE in non-excitable cells

Antibiotic; inhibits protein, DNA and RNA synthesis in gram-positive bacteria

Hdm2 inhibitor; activates p53-dependent transcription

Vitamin D receptor (VDR) agonist

Selective PKD inhibitor; analog of CID744673 (Cat.No. 3327).

Positive allosteric modulator of α4β2

Selective sigma (σ) agonist (σ₁> σ₂)

Hsp70 inhibitor

Inhibits IP₃-mediated Ca²⁺ release

Inhibitor of ROMK and Kir7.1; Kir1.1 channel pore blocker

Class III PI 3-kinase inhibitor; also inhibits autophagy

Dynamin inhibitor; attenuates mitochondrial divsion and apoptosis

5-HT_2A/D₂ antagonist; atypical antipsychotic

Selective estrogen receptor modulator (SERM)

Selective P2Y₆ agonist

Inhibitor of calcineurin-mediated NFAT activation

Selective α₄β₁ (VLA-4) inhibitor

Selective PKCε activator

Selective GSK-3 inhibitor

Potent and selective RXRα agonist.

Potent and selective MCH₁ antagonist

JAK2/STAT3 signaling pathway inhibitor

Fluorescent substrate for VMAT2

Control peptide for NPY (Cat. No. 1173).

Potent and selective NOP agonist

Estrogen receptor ligand; mycotoxin

RXR antagonist

D₃ antagonist. Also D₂ partial agonist

Selective secreted phospholipase A₂ (sPLA₂) inhibitor

Potent inhibitor of ER-associated protein degradation and translocation

Selective inhibitor of PTPMT1

Subtype-selective GABA_A receptor agonist

Potent and selective PPARδ antagonist

Competitive thioredoxin-1 inhibitor

Human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor

PAR₂ receptor agonist

Selective ERRα antagonist/inverse agonist

Mycotoxin; potent protein synthesis inhibitor

Selective inhibitor of TGF-βRI

Deuterated nalmefene; opioid receptor antagonist

MDMX inhibitor. Disrupts MDMX-p53 interaction

Selective ERK inhibitor

Selective P2Y₁₁ antagonist

Active metabolite of oxcarbazepine (Cat. No. 3864)

Prodrug form of FTI 276 (Cat. No. 2406)

Farnesyltransferase (FTase) inhibitor; antitumor

Dopamine D₂/D₃ agonist

Potent NOP agonist; displays analgesic properties

Active metabolite of vitamin D₂

TRPA1 blocker

Potent thrombin inhibitor

Inactive analog of BIO (Cat. No. 3194)

KCC2 inhibitor

Commonly used laboratory reagent

Commonly used laboratory reagent

Commonly used laboratory reagent

Commonly used laboratory reagent

Commonly used laboratory reagent

H₁ antagonist. Also hERG and K_ATP channel blocker

Sodium salt of DL-AP5 (Cat. No. 0105)

Calcium channel blocker

Downregulates Bcl-2 and Mcl-1; pro-apoptotic

μ-opioid receptor agonist

Selective mGlu₅ agonist. Sodium salt of CHPG (Cat.No. 1049)

Cell-permeable inhibitor of CK2; also inhibits Pim kinase and PKD1

Potent inhibitor of multi-drug and toxin extrusion (MATE) transporters; also inhibits DHFR

Positive allosteric modulator of α7 nAChR

Selective P2Y₁₂ antagonist

Selective Rho-kinase (ROCK) inhibitor

GSK-3β inhibitor; induces neuronal differentiation in ESCs

PDE3 inhibitor

Selective, high affinity 5-HT_1A receptor antagonist

Axin stabilizer; promotes β-catenin phosphorylation

Potent, selective Rho-kinase (ROCK) inhibitor

Inhibitor of macrophage migration inhibitor factor (MIF); suicide substrate

Topoisomerase II inhibitor

TRPV1 antagonist

Selective PARP-1 inhibitor

Positive modulator of SK and IK channels

Antibiotic; inhibits bacterial DNA synthesis

Orally active p38α and p38β inhibitor

5-HT_1B/1D agonist

Selective REV-ERBα agonist

Ca²⁺ mobilizing agent

PARP-2 inhibitor

Non-immunogenic adjuvant

GAPDH inhibitor. Neuroprotective

Wnt production inhibitor; inactivates porcn

Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist

Selective cyclooxygenase-2 (COX-2) inhibitor

Synthetic retinoid. RARβ agonist; also RARα and RARγ antagonist

Selective 5-HT_1D agonist

Positive allosteric modulator of M₄ receptors

Selective nNOS inhibitor

Non-steroidal androgen receptor antagonist

Potent Src inhibitor; also inhibits FGFR1, PDGFRβ and Wee1

Selective S1P₁ receptor agonist

β-catenin binder; inhibits wnt signaling

Potent EP₁ receptor antagonist

Triazole antifungal agent

Selective P2Y₂ agonist

KISS1/GPR54 antagonist; kisspeptin 10 analog

Endogenous σ1 ligand. Also 5-HT_2A agonist

NPY Y₂ receptor antagonist

Selective TRPC3 channel inhibitor

MCH₁ antagonist; also 5-HT_2B antagonist and partial antagonist of 5-HT_1A

Potent, dual orexin receptor antagonist

Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity

Potent NPY Y₅ antagonist

Hec1 inhibitor; causes arrest of mitosis

Potent aryl hydrocarbon receptor (AhR) antagonist

Potent, specific and reversible inhibitor of GBF1 ArfGEF

Selective soluble adenylyl cyclase inhibitor

Selective VEGFR-2 inhibitor

Selective VEGFR-2 inhibitor

Selective cyclooxygenase-2 (COX-2) inhibitor; NSAID

Cannabinoid receptor agonist; not psychoactive

Sustains self-renewal and pluripotency of ESCs

Induces cardiomyogenesis in ESCs

Anti-inflammatory; causes mast cell degranulation and histamine release

Stimulates Bcl-XL mRNA transcription; antiapoptotic

p53 inhibitor

Potent and selective I_Ks blocker

Pan RXR agonist

Antibiotic; inhibits bacterial type II topoisomerase

FPR agonist

Potent P2X₄ receptor antagonist

Selective chymase substrate

Myristoylated form of pep2m. Peptide inhibitor of GluR2 subunit binding to NSF

Potent and selective H₄ receptor antagonist

Selective GSK-3α/β inhibitor

Potent and selective H₄ antagonist

Irreversible inhibitor of MAO-A, MAO-B and LSD1

Potent and selective PLD₁ inhibitor

Histone deacetylase inhibitor

Anticonvulsant; inhibits Na⁺ channel activity

Histone deacetylase inhibitor

Potent and selective NOP antagonist

DNA methyltransferase inhibitor

Highly selective A₁ agonist

Selective inhibitor of TrioN RhoGEF activity

Aminopeptidase inhibitor

Negative control for SNOB 1 (Cat. No. 3879)

Detects S-nitrosylated proteins

Naturally occurring anthraquinone; displays anti-inflammatory, antitumor and neuroprotective activity

Potent and selective ERβ agonist

Aryl hydrocarbon receptor antagonist

K_ATP channel blocker

Potent and selective NPY Y₅ antagonist

Selective, nonpeptide AT₁ antagonist

Prolongs inactivation of sodium channels; anticonvulsant

Potent and selective PI 3-kinase γ (PI3Kγ) inhibitor

TrkB agonist

Potent inhibitor of Rac family GTPases

Potent, reversible MAGL inhibitor

Inhibitor of NF-κB activation; anti-inflammatory

Dual PI 3-kinase and PDK1 inhibitor

Glutamate receptor ligand

Potent endogenous MCH agonist

GABA agonist and glutamatergic modulator

Selective α₂ antagonist

Antibiotic; inhibits bacterial DNA synthesis

Orally active, selective 5-HT_1B/1D agonist

Cell-permeable inhibitor of eIF2α dephosphorylation

Orally active, potent PDE5 inhibitor

Triazole antifungal agent