R&D Systems Inc. Tocris Bioscience Boston Biochem

New Products

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New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the new products can be identified by this symbol symbol.

If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.

Cat.No.
Product Name / Activity
Added
5154HNGF6A

Humanin analog; increases insulin sensitivity

Apr 2014
5145AI-3

ARE activator; induces Nrf2-ARE-dependent transcription

Apr 2014
4949MaxiPost

Positive channel modulator; exerts subtype-specific effects

Apr 2014
5168Rose Bengal

Potent EAAT and VMAT inhibitor; cell permeable

Apr 2014
5111GSK 1838705

Potent and selective IR and IGF1R inhibitor; antitumor

Apr 2014
4826SUN 11602

Basic fibroblast growth factor (bFGF) mimetic; neuroprotective

Apr 2014
5167Congo Red

EAAT inhibitor; also an amyloid fibril-binding dye

Apr 2014
5144CFM 4

CARP-1 mimetic; proapoptotic

Apr 2014
5119Calcein AM

Cell permeable compound which is hydrolyzed to become fluorescent in living cells

Apr 2014
4766SIB 1508Y maleate

Potent agonist of α4β2, α2β4, α4β4 and α3β4 nACh receptors

Apr 2014
4569PS 1145 dihydrochloride

Selective IKK inhibitor; orally active

Apr 2014
5132UNC 0642

Potent and selective G9a and GLP histone lysine methyltransferase inhibitor

Apr 2014
5118SynaptoRedTM C2

Fluorescent dye; stains synaptic vesicles

Apr 2014
5072PFI 3

Potent and selective SMARCA4 and polybromo 1 inhibitor; also inhibits SMARCA2

Apr 2014
5065NSC 319726

Reactivator of mutant p53

Apr 2014
5035AS 2034178

Selective FFA1 (GPR40) agonist

Apr 2014
4969LY 2389575 hydrochloride

Selective negative allosteric modulator of mGlu3

Apr 2014
4777ML 277

Selective Kv7.1 (KCNQ1) potassium channel activator; augments IKs current

Apr 2014
4763Pyridostatin pentahydrochloride

Stabilizes G-quadruplexes; inducing DNA damage and cell cycle arrest

Apr 2014
4605(±)-SLV 319

Potent and selective CB1 receptor antagonist

Apr 2014
4892(R)-PFI 2 hydrochloride

Potent and selective SETD7 histone lysine methyltransferase inhibitor

Mar 2014
4528(±)-NBI 74330

Potent and selective CXCR3 antagonist

Mar 2014
5138RSVA 405

AMPK activator

Mar 2014
5025Necrosulfonamide

Necroptosis inhibitor

Mar 2014
4924CEP 1347

Inhibitor of JNK signaling

Mar 2014
4643PCI 34051

Potent and selective histone deacetylase 8 (HDAC8) inhibitor; induces apoptosis in T cell-derived cell lines

Mar 2014
4580Atiprimod dihydrochloride

JAK2 Inhibitor

Mar 2014
4551Purmorphamine

Smo receptor agonist

Mar 2014
5158Morphine hydrochloride

Narcotic opioid analgesic

Mar 2014
5146Sulforhodamine 101

Fluorescent dye; selective astrocyte marker

Mar 2014
5130CTCE 9908

CXCR4 antagonist; antitumor

Mar 2014
5126iMDK

Potent suppressor of MDK expression; antitumor

Mar 2014
5074ANQ 11125

Selective motilin receptor antagonist

Mar 2014
5041PAOPA

Dopamine D2 receptor allosteric modulator

Mar 2014
4976ML 289

Selective negative allosteric modulator at mGlu3

Mar 2014
4946AIM 100

Potent and selective Ack1 inhibitor

Mar 2014
4899ML 120B dihydrochloride

Novel IKK2-selective inhibitor

Mar 2014
4859ML 202

Pyruvate kinase M2 activator

Mar 2014
4780VUF 11207 fumarate

Potent CXCR7 agonist

Mar 2014
4747TC-G 1006

Potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonist

Mar 2014
4697A 331440 dihydrochloride

Selective H3 antagonist

Mar 2014
3322ZD 9379

Brain penetrant NMDA antagonist, acts at glycine site

Mar 2014
5160Medetomidine hydrochloride

Potent, highly selective α2 agonist

Mar 2014
5143Ononetin

TRPM3 blocker

Mar 2014
5115OXA (17-33)

Potent and selective peptide OX1 antagonist

Mar 2014
5082LDN 212320

Increases EAAT2 expression; neuroprotective

Mar 2014
4983ACT 335827

Potent and selective OX1 antagonist

Mar 2014
4130KN 92

Inactive analog of KN 93. K+ channel (Kv) blocker

Mar 2014
5157DMNPE-caged ATP diammonium salt

Caged ATP

Feb 2014
5156Ivermectin B1a-d2

Deuterated ivermectin B1a (Cat. No. 1260)

Feb 2014
4977RN 1 dihydrochloride

LSD1 inhibitor

Feb 2014
4908GNF 5

Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)

Feb 2014
4872KML 29

Highly selective and potent monoacylglycerol lipase (MAGL) inhibitor

Feb 2014
4808FK 866 hydrochloride

Nicotinamide phosphoribosyltransferase (NMPRTase) inhibitor; induces apoptosis; induces autophagy

Feb 2014
4778BETP

Positive allosteric modulator of GLP-1 receptors

Feb 2014
4673SB 674042

Potent and selective non-peptide OX1 antagonist

Feb 2014
5096AdipoRon hydrochloride

Orally active AdipoR1 and AdipoR2 agonist; antidiabetic

Feb 2014
5094PG 931

Potent and selective MC4 receptor agonist

Feb 2014
5085L 012 sodium salt

Chemiluminescent ROS and RNS indicator

Feb 2014
5045L002

p300 inhibitor

Feb 2014
4994PYZD 4409

Ubiquitin-activating enzyme (E1) inhibitor

Feb 2014
4883CU CPT 4a

Selective TLR3 antagonist

Feb 2014
4866ML 190

Selective κ opioid receptor antagonist

Feb 2014
4603LUF 5834

Potent adenosine A2A and A2B receptor partial agonist

Feb 2014
4173MDL 100907

Potent and selective 5-HT2A antagonist

Feb 2014
4078PF 8380

Potent autotaxin inhibitor

Feb 2014
5147Istradefylline

Potent and selective adenosine A2A receptor antagonist

Feb 2014
5139Telmisartan

AT1 antagonist; PPARγ partial agonist

Feb 2014
5136Rizatriptan benzoate

Potent 5-HT1B/1D agonist

Feb 2014
5117Hoechst 33342

Fluorescent DNA stain

Feb 2014
4951SA 4503 dihydrochloride

Selective σ1 receptor agonist

Feb 2014
4622MK 1903

Potent and selective GPR109A (HCA2) agonist

Feb 2014
4550IQ 3

Selective JNK3 inhibitor

Feb 2014
4459TC-S 7005

Potent and selective PLK2 inhibitor

Feb 2014
4288ISO 1

Macrophage migration inhibitory factor (MIF) inhibitor

Feb 2014
3824CD 2314

Selective RARβ agonist

Feb 2014
5092Acridine Orange hydrochloride

Nucleic acid binding dye

Feb 2014
5063SRPIN340

Selective SRPK1 inhibitor

Feb 2014
5102PLX 647 dihydrochloride

Potent dual Fms/KIT inhibitor

Jan 2014
4917M 25

Potent Smoothened (Smo) receptor antagonist

Jan 2014
4865APY 29

Inhibits IRE1α autophosphorylation; activates IRE1α endoribonuclease activity

Jan 2014
4689GSK J5

Inactive isomer of GSK J4 (Cat. No. 4594); cell permeable

Jan 2014
4688GSK J2

Inactive isomer of GSK-J1 (Cat. No. 4593)

Jan 2014
5022BMS 599626 dihydrochloride

Potent, selective EGFR and ErbB2 inhibitor

Jan 2014
4632TC-I 2000

TRPM8 blocker

Jan 2014
5071NKY 80

Adenylyl cyclase inhibitor

Jan 2014
5066ICA 121431

Selective NaV1.3 and NaV1.1 blocker

Jan 2014
5054ME 0328

Selective PARP-3 inhibitor

Jan 2014
4948CYM 50769

Novel non-peptide NPBWR1 antagonist

Jan 2014
4907SN 2

Selective TRPML3 channel activator

Jan 2014
4906JW 642

Monoacylglycerol (MAGL) inhibitor

Jan 2014
440610058-F4

Inhibits c-Myc-Max dimerization

Jan 2014
4756COR 170

Selective CB2 receptor inverse agonist

Jan 2014
4452GGsTop

Inhibitor of γ-glutamyl transpeptidase (GGT)

Jan 2014
4936Clozapine N-oxide

Clozapine (Cat. No. 0444) metabolite

Dec 2013
4869SR 2211

Selective RORγ inverse agonist

Dec 2013
48004EGI-1

Inhibitor of eIF4E:eIF4G interaction

Dec 2013
4838AZ 12080282 dihydrochloride

Inhibitor of Hedgehog (Hh) signaling

Dec 2013
4315NGD 98-2 hydrochloride

High affinity CRF1 antagonist

Dec 2013
5069Teriflunomide

Dihydroorotate dehydrogenase inhibitor

Dec 2013
4986K 02288

BMP inhibitor; displays some selectivity for ALK2

Dec 2013
4868SR 1001

RORα/γ inverse agonist

Dec 2013
4572TC-E 5005

Potent and selective PDE10A inhibitor

Dec 2013
4240SCH 529074

Restores mutant p53 activity

Dec 2013
3567TC-S 7003

Potent Lck inhibitor

Dec 2013
5081J 147

Neurotrophic compound. Reduces Aβ40 and Aβ42 levels

Dec 2013
5062Cyclotraxin B

TrkB receptor antagonist

Dec 2013
5056Ki 16425

LPA1 and LPA3 receptor antagonist

Dec 2013
5055Qc 1

Threonine dehydrogenase inhibitor

Dec 2013
4982ML 337

Selective negative allosteric modulator of mGlu3

Dec 2013
4880ML 281

STK33 inhibitor

Dec 2013
4874SR 1078

RORα/γ agonist

Dec 2013
4715JZL 195

Dual FAAH and MAGL inhibitor

Dec 2013
4679CYM 50358 hydrochloride

Potent and selective S1P4 antagonist

Dec 2013
4407TC-G 1004

Potent and selective A2A antagonist

Dec 2013
4996PMX 464

Putative inhibitor of the Trx-TrxR system; antiproliferative

Dec 2013
4975CRT 0066101

Potent protein kinase D (PKD) inhibitor

Dec 2013
4954UAMC 00039 dihydrochloride

Dipeptidyl peptidase II (DPP-II) inhibitor

Dec 2013
4851Stoppin 2

Competitive p53-MDM2/MDMX interaction inhibitor

Dec 2013
5075Harmine

Potent and selective Dyrk1A inhibitor

Nov 2013
50341,9-Dideoxyforskolin

Inactive analog of forskolin (Cat. No. 1099)

Nov 2013
4995Phortress

Prodrug of the antitumor agent 5F 203

Nov 2013
4989Salirasib

Ras inhibitor; also induces autophagy

Nov 2013
4972JIB 04

Pan Jumonji histone demethylase inhibitor; active in vivo

Nov 2013
4836AZ 628

Potent Raf kinase inhibitor

Nov 2013
4788NS 11021

Activator of BKCa (KCa1.1) channels

Nov 2013
4612URB 597

Potent and selective FAAH inhibitor

Nov 2013
4487(±)-AMG 487

CXCR3 antagonist; inhibits cell migration and metastasis

Nov 2013
29626'-GNTI dihydrochloride

Selective κ/δ opioid heterodimer receptor agonist

Nov 2013
5064LY 379268 disodium salt

Sodium salt of LY 379268 (Cat. No. 2453); selective group II mGlu receptor agonist

Nov 2013
5049TC-E 5001

Tankyrase inhibitor

Nov 2013
5047PRT 4165

Inhibitor of Bmi1/Ring1A

Nov 2013
5032Talampanel

Non-competitive AMPA/kainate antagonist

Nov 2013
4672SB 223412

Potent, selective non-peptide NK3 antagonist. Brain penetrant

Nov 2013
3515FK 228

Potent and selective class I histone deacetylase inhibitor; antitumor

Nov 2013
1992Nomifensine

Potent noradrenalin and dopamine uptake inhibitor. Antidepressant

Nov 2013
4953CHIR 99021 trihydrochloride

Hydrochloride salt of CHIR 99021 (Cat. No. 4423); selective GSK-3 inhibitor

Nov 2013
4895ML 298 hydrochloride

Selective PLD2 inhibitor

Nov 2013
4797Org 37684

5-HT2 agonist

Nov 2013
4787CPPHA

Positive allosteric modulator at mGlu1 and mGlu5

Nov 2013
5048YZ9

PFKFB3 inhibitor; inhibits cell growth

Nov 2013
5028GMQ hydrochloride

ASIC3 opener

Nov 2013
4858NSC 697923

Selective inhibitor of E2 ubiquitin-conjugating enzyme Ubc13-Uev1A

Nov 2013
4858NSC 697923

Selective inhibitor of E2 ubiquitin-conjugating enzyme Ubc13-Uev1A

Nov 2013
4840KU 0060648

Dual DNA-PK and PI 3-K inhibitor

Nov 2013
4478GPBAR-A

Bile acid receptor TGR5 (GPBA) agonist

Nov 2013
4334PSB 0777 ammonium salt

Potent adenosine A2A agonist

Nov 2013
4835GPP 78 hydrochloride

NMPRTase inhibitor; also induces autophagy

Oct 2013
4785SA 47

Selective FAAH inhibitor

Oct 2013
4668GW 627368

Selective EP4 receptor competitive antagonist

Oct 2013

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