R&D Systems Inc. Tocris Bioscience Boston Biochem

New Products

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New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the new products can be identified by this symbol symbol.

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Cat.No.
Product Name / Activity
Added
5280SCH 51344

Potent MTH1 inhibitor

Sep 2014
5215KN 93 phosphate

CaM kinase II inhibitor; water soluble version of KN-93 (Cat. No. 1278).

Sep 2014
5183ETP 45835 dihydrochloride

Mnk1 and Mnk2 inhibitor

Sep 2014
5163A 366

Potent and selective G9a/GLP histone lysine methyltransferase inhibitor

Sep 2014
5140GSK 2830371

Potent and selective allosteric inhibitor of Wip1 phosphatase

Sep 2014
3565ONO AE3 208

High affinity and selective EP4 antagonist

Sep 2014
5238Bryostatin 3

Potent protein kinase C activator

Sep 2014
5189GSK 2837808A

Potent and selective LDHA inhibitor

Sep 2014
5292Cladribine

Deoxyadenosine analog; pro-apoptotic

Sep 2014
5270Toyocamycin

Adenosine analog antifungal antibiotic

Sep 2014
5258BMS 309403

Potent and selective FABP4 inhibitor

Sep 2014
3591VO-OHpic

Potent PTEN inhibitor

Sep 2014
5207STF 118804

NAMPT inhibitor

Sep 2014
5133GKA 50

Glucokinase activator

Sep 2014
4244TCS 3035

GPR35 agonist

Sep 2014
5263Bazedoxifene acetate

Potent and selective estrogen receptor modulator (SERM), selective for ERα

Sep 2014
5262PF 5274857 hydrochloride

Potent and selective smoothened (Smo) receptor antagonist

Sep 2014
5251UC 112

IAP and XIAP inhibitor; antitumor

Aug 2014
5235Huwentoxin XVI

Potent and reversible N-type Ca2+ channel blocker

Aug 2014
5155SGI 1027

DNA methyltransferase inhibitor

Aug 2014
4753AL 8697

Potent and selective p38α inhibitor

Aug 2014
4303PPQ 102

Potent, voltage-independent CFTR chloride channel inhibitor

Aug 2014
4161Paricalcitol

Analog of the active form of vitamin D2

Aug 2014
4148Abacavir hemisulfate

Reverse transcriptase inhibitor; antiretroviral

Aug 2014
5257GSK 137647

Potent and selective FFA4 (GPR120) agonist

Aug 2014
5256AH 7614

Selective FFA4 (GPR120) antagonist

Aug 2014
5134MRT 67307 dihydrochloride

Salt inducible kinase (SIK) inhibitor

Aug 2014
4952TRAM 39

Potent KCa3.1 blocker

Aug 2014
4828LDN 209929 dihydrochloride

Potent and selective haspin kinase inhibitor

Aug 2014
5231MPC 6827 hydrochloride

Inhibitor of microtubule polymerization; antimitotic and antitumor

Aug 2014
5196PMX 205

Potent C5a receptor peptide antagonist

Aug 2014
5191PTC 209

Bmi-1 inhibitor; antitumor

Aug 2014
4150Azidothymidine

Selective reverse transcriptase inhibitor; antiretroviral

Aug 2014
3909Toceranib

Potent PDGFR and VEGFR inhibitor

Aug 2014
52556-Bnz-cAMP sodium salt

Cell permeable cAMP analog

Aug 2014
5247NVP ADW 742

ATP-competitive inhibitor of IGF1R

Aug 2014
5186Neuropathiazol

Selective inducer of neuronal differentiation

Aug 2014
5061RKI 1447 dihydrochloride

Potent and selective ROCK inhibitor; antitumor

Aug 2014
4963SC 144 hydrochloride

gp130 inhibitor; blocks cytokine-triggered gp130 signaling

Aug 2014
5254FH 1

Enhances iPSC-derived hepatocyte differentiation and maturation

Jul 2014
5223Monensin sodium salt

Sodium ionophore; antibacterial agent

Jul 2014
5213LL 37

Antimicrobial peptide derivative of human cathelicidin

Jul 2014
5171NBOH-2C-CN hydrochloride

Potent and selective 5-HT2A agonist

Jul 2014
5109SB 743921 hydrochloride

Potent kinesin spindle protein (KSP) inhibitor

Jul 2014
5068ITD 1

Selective inhibitor of TGF-β signaling; induces cardiomyocyte differentiation in ESCs

Jul 2014
5250Ramipril

Non-peptide, competitive angiotensin converting enzyme (ACE) inhibitor

Jul 2014
5173MS 436

Potent and selective BRD4 bromodomain inhibitor

Jul 2014
5161ML 154

Potent neuropeptide S receptor (NPSR) antagonist

Jul 2014
4767WAY 316606 hydrochloride

Secreted frizzled-related protein-1 (sFRP-1) inhibitor; increases Wnt signaling

Jul 2014
4734TRC 051384

Inducer of heat shock protein Hsp70

Jul 2014
5228Urea

Used to solubilize and denature proteins

Jul 2014
5227Tricine

Electrophoresis buffer

Jul 2014
5226Sodium phosphate monobasic

Commonly used in biological assay buffers

Jul 2014
5225Ponceau S Staining Solution

Stain used to detect protein bands after Western blotting

Jul 2014
5224MTT

Reagent used in the measurement of cell proliferation

Jul 2014
5222Hematoxylin

Dye used to stain cell nuclei

Jul 2014
5221Guanidine Hydrochloride

Protein denaturant

Jul 2014
5220Glycerol

Widely used in sample buffer preparation

Jul 2014
5219L-Glutathione Reduced

Endogenous antioxidant

Jul 2014
5218Bromophenol Blue

Dye used in gel loading buffers

Jul 2014
5217Bovine Serum Albumin

Widely used blocking agent for ELISA and blotting

Jul 2014
5216BIS-TRIS

Commonly used buffering agent

Jul 2014
5095DBM 1285 dihydrochloride

p38 MAPK inhibitor; anti-inflammatory

Jul 2014
4993NSC 624206

Ubiquitin-activating enzyme (E1) inhibitor

Jul 2014
4169KS 176

Selective BCRP inhibitor

Jul 2014
4139Aprotinin

Competitive serine protease inhibitor

Jul 2014
3177Boric acid

Widely used in buffers for electrophoresis

Jul 2014
3166Sodium dodecyl sulphate solution

Detergent used in electrophoresis of proteins

Jul 2014
3165Polyoxyethylenesorbitan monolaurate

Detergent used for protein extraction

Jul 2014
3156Dulbecco's PBS

Buffered saline used in mammalian cell culture

Jul 2014
3153Sodium phosphate dibasic

Commonly used in biological assay buffers

Jul 2014
3150Potassium phosphate monobasic

Commonly used in biological assay buffers

Jul 2014
5245Ebselen

Glutathione peroxidase mimic; peroxynitrite scavenger

Jul 2014
5230BRD 7552

PDX1 transcription factor inducer; increases insulin expression

Jul 2014
5184BDS I

Potent and reversible Kv3.4 potassium channel blocker; neuroprotective

Jul 2014
4745LIMKi 3

Potent LIM kinase inhibitor; antitumor

Jul 2014
4694Ro 5-3335

Core binding factor inhibitor; attenuates hematopoiesis

Jul 2014
4625TC OT 39

Nonpeptide oxytocin and V2 receptor partial agonist; also a V1a receptor antagonist

Jul 2014
5190FRAX 486

Potent p21-activated kinase (PAK) inhibitor; brain penetrant and orally bioavailable

Jul 2014
5179TCID

Selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor

Jul 2014
5141AZD 5582 dihydrochloride

Dimeric Smac mimetic; potent IAP inhibitor

Jul 2014
50332-MPPA

Selective glutamate carboxypeptidase II (GCP II) inhibitor; orally bioavailable

Jul 2014
4842BIX 02189

Selective MEK5 and ERK5 inhibitor

Jul 2014
4783Lu AA 47070

Prodrug of a potent and selective adenosine A2A receptor antagonist

Jul 2014
4750TC Mps1 12

Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor; orally active

Jul 2014
2472Triacsin C

Inhibitor of acyl-CoA synthetase

Jul 2014
5208E 64

Potent and irreversible cysteine protease inhibitor

Jun 2014
5195Agitoxin 2

Potent Shaker K+ channel blocker

Jun 2014
5181Tolvaptan

Potent and selective vasopressin V2 receptor antagonist; renoprotective and orally active

Jun 2014
5107GSK 2606414

Potent and selective PERK inhibitor; orally bioavailable

Jun 2014
5044SR 3576

Highly potent and selective JNK3 inhibitor

Jun 2014
5198AZ 20

Potent and selective ATR kinase inhibitor; antitumor

Jun 2014
4945ML 347

Potent and selective ALK1 and ALK2 inhibitor

Jun 2014
5199AZD 7762 hydrochloride

Potent and selective ATP-competitive inhibitor of Chk1 and Chk2

Jun 2014
5098KRCA 0008

Potent Ack1 and ALK dual inhibitor; orally bioavailable

Jun 2014
5077DDR1-IN-1 dihydrochloride

Selective DDR1 inhibitor

Jun 2014
4888KHS 101 hydrochloride

Selective inducer of neuronal differentiation

Jun 2014
5086PA 452

RXR antagonist

Jun 2014
5005DR 4485 hydrochloride

High affinity and selective 5-HT7 antagonist; orally bioavailable

Jun 2014
4854ML 00253764 hydrochloride

Melanocortin MC4 receptor antagonist; brain penetrant

Jun 2014
4598PHT 427

Dual Akt and PDK1 inhibitor; antitumor

Jun 2014
5175AEBSF

Broad spectrum, irreversible inhibitor of serine proteases

May 2014
5110GSK 1562590 hydrochloride

High affinity, selective urotensin II (UT) receptor antagonist

May 2014
5051BIO 5192

Highly potent and selective inhibitor of integrin α4β1

May 2014
5021TC-G 1000

Potent and selective α2D agonist

May 2014
5169Noradrenaline bitartrate

Endogenous adrenergic hormone and neurotransmitter

May 2014
5180Ferrostatin 1

Selective inhibitor of erastin induced ferroptosis

May 2014
5151Prosaptide TX14(A)

Potent GPR37 and GPR37L1 agonist

May 2014
5113AbK

Photo-crosslinking probe

May 2014
5036ML 786 dihydrochloride

Potent Raf kinase inhibitor; orally bioavailable

May 2014
4886RU-SKI 43 hydrochloride

Hedgehog acyltransferase (Hhat) inhibitor; cell permeable

May 2014
4875Senexin A

Cyclin-dependent kinase 8 (cdk8) inhibitor

May 2014
2305Tautomycetin

Selective PP1 inhibitor

May 2014
5172FLI 06

Inhibitor of Notch signaling

May 2014
5148Wnt-C59

Highly potent Porcn inhibitor

May 2014
5128C 21

Selective PRMT1 arginine methyltransferase inhibitor

May 2014
4964R 1485 dihydrochloride

Selective and high affinity 5-HT6 antagonist

May 2014
1286LY 231617

Antioxidant; neuroprotective in vitro and in vivo

May 2014
5099TC-E 5003

Selective PRMT1 arginine methyltransferase inhibitor

May 2014
5050CASIN

Cdc42 GTPase inhibitor

May 2014
4978Pyrintegrin

Enhances survival of human ESCs following enzymatic dissociation

May 2014
4934MA 2029

Potent and selective, competitive motilin receptor antagonist; orally active

May 2014
4898TC-E 5006

γ-secretase modulator; reduces Aβ42 levels

May 2014
5135Propidium iodide

Red-fluorescent DNA stain; membrane impermeant to live cells

Apr 2014
5106GSK 2193874

Potent and selective TRPV4 inhibitor; orally active

Apr 2014
5076SZL P1-41

Selective Skp2 inhibitor; suppresses E3 ligase activity

Apr 2014
4893XL 388

Potent and selective mTOR inhibitor; antitumor

Apr 2014
4604PTIQ

Potent MMP-3 expression inhibitor; neuroprotective

Apr 2014
4557GTS 21 dihydrochloride

Partial agonist at α7 nAChR

Apr 2014
5154HNGF6A

Humanin analog; increases insulin sensitivity

Apr 2014
5145AI-3

ARE activator; induces Nrf2-ARE-dependent transcription

Apr 2014
4949MaxiPost

Potassium channel modulator; exerts subtype-specific effects

Apr 2014
5168Rose Bengal

Potent VGlut and VMAT inhibitor; cell permeable

Apr 2014
5111GSK 1838705

Potent and selective IR and IGF1R inhibitor; antitumor

Apr 2014
4826SUN 11602

Basic fibroblast growth factor (bFGF) mimetic; neuroprotective

Apr 2014
5167Congo Red

Amyloid fibril binding dye; also a VGlut inhibitor

Apr 2014
5144CFM 4

CARP-1 mimetic; proapoptotic

Apr 2014
5119Calcein AM

Cell permeable compound; hydrolyzed to become fluorescent in living cells

Apr 2014
4766SIB 1508Y maleate

Potent agonist of α4β2, α2β4, α4β4 and α3β4 nACh receptors

Apr 2014
4569PS 1145 dihydrochloride

Selective IKK inhibitor; orally active

Apr 2014

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