R&D Systems Inc. Tocris Bioscience Boston Biochem

New Products

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New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the new products can be identified by this symbol symbol.

If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.

Cat.No.
Product Name / Activity
Added
5335Angiotensin A

Potent endogenous vasoconstrictor peptide - derivative of angiotensin II (Cat. No. 1158)

Nov 2014
5315Rostafuroxin

Antihypertensive agent; Na+/K+ ATPase modulator

Nov 2014
5310ASP 3026

Potent anaplastic lymphoma kinase (ALK) inhibitor

Nov 2014
5285ZLN 024 hydrochloride

Allosteric AMPK activator

Nov 2014
5283HLM 006474

E2F transcription factor inhibitor

Nov 2014
5040SB 706504

p38 MAPK inhibitor

Nov 2014
4518EPPTB

Trace amine-associated receptor 1 (TA1) antagonist/inverse agonist

Nov 2014
5325Rosiglitazone

Potent and selective PPARγ agonist; antidiabetic agent.

Nov 2014
5313LY 315920

Selective secreted phospholipase A2 (sPLA2) inhibitor

Nov 2014
5272MK 0677

High affinity ghrelin receptor agonist

Nov 2014
5266BAZ2-ICR

Selective BAZ2 bromodomain inhibitor

Nov 2014
4958Eplivanserin hemifumarate

Potent and selective 5-HT2A antagonist

Nov 2014
5289OF 1

Selective BRPF1B and BRPF2 bromodomain inhibitor

Nov 2014
5261Dimethylenastron

Inhibitor of mitotic motor kinesin Eg5

Nov 2014
5296Urantide

Selective and competitive urotensin II antagonist

Oct 2014
5277CCG 203971

Inhibits the MRTF/SRF gene transcription pathway; antifibrotic agent

Oct 2014
5275LSN 2463359

Potent and selective positive allosteric modulator at mGlu5

Oct 2014
5264Temsirolimus

mTOR inhibitor; antitumor

Oct 2014
5203NIBR 189

Potent and selective EBI2 (GPR183) receptor antagonist

Oct 2014
5188S 07662

Inverse agonist of the constitutive androstane receptor (CAR)

Oct 2014
5112NS 9283

Positive allosteric modulator of α4β2

Oct 2014
5084MN 64

Potent and selective tankyrase inhibitor

Oct 2014
5290KYL

EphA4 receptor tyrosine kinase antagonist; neuroprotective

Oct 2014
5101PD 90780

Inhibits NGF binding to p75NTR

Oct 2014
4701EC 144

High affinity, potent and selective Hsp90 inhibitor

Oct 2014
4691NAV 26

Selective Nav1.7 channel blocker

Oct 2014
3856RuBi-5-HT

RuBi-caged serotonin

Oct 2014
5268Tocriscreen Epigenetics Toolbox

80 Epigenetic modulators supplied pre-dissolved in DMSO (250 μL 10 mM solutions)

Oct 2014
5248XAP 044

Potent and selective mGlu7 antagonist

Oct 2014
5122Dansyl-NECA

Potent and selective fluorescent adenosine A1 agonist

Oct 2014
5046LM11A 31 dihydrochloride

Nonpeptide p75NTR ligand; neuroprotective

Oct 2014
4931EG 00229

Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1

Oct 2014
5089TC-E 5002

Selective histone demethylase KDM2/7 subfamily inhibitor

Oct 2014
4928OXF BD 02

Selective BRD4(1) inhibitor

Oct 2014
4776BIRT 377

Potent negative allosteric modulator of LFA-1

Oct 2014
4724BTT 3033

Selective inhibitor of integrin α2β1

Oct 2014
5280SCH 51344

Potent MTH1 inhibitor

Sep 2014
5215KN 93 phosphate

CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278).

Sep 2014
5183ETP 45835 dihydrochloride

Mnk1 and Mnk2 inhibitor

Sep 2014
5163A 366

Potent and selective G9a/GLP histone lysine methyltransferase inhibitor

Sep 2014
5140GSK 2830371

Potent and selective allosteric inhibitor of Wip1 phosphatase

Sep 2014
3565ONO AE3 208

High affinity and selective EP4 antagonist

Sep 2014
5238Bryostatin 3

Potent protein kinase C activator

Sep 2014
5189GSK 2837808A

Potent and selective LDHA inhibitor

Sep 2014
5292Cladribine

Deoxyadenosine analog; pro-apoptotic

Sep 2014
5270Toyocamycin

Adenosine analog; antifungal antibiotic

Sep 2014
5258BMS 309403

Potent and selective FABP4 inhibitor

Sep 2014
3591VO-OHpic

Potent PTEN inhibitor

Sep 2014
5207STF 118804

NAMPT inhibitor

Sep 2014
5133GKA 50

Glucokinase activator

Sep 2014
4244TCS 3035

GPR35 agonist

Sep 2014
5263Bazedoxifene acetate

Potent and selective estrogen receptor modulator (SERM), selective for ERα

Sep 2014
5262PF 5274857 hydrochloride

Potent and selective Smoothened (Smo) receptor antagonist

Sep 2014
5251UC 112

IAP and XIAP inhibitor; antitumor

Aug 2014
5235Huwentoxin XVI

Potent and reversible N-type Ca2+ channel blocker

Aug 2014
5155SGI 1027

DNA methyltransferase inhibitor

Aug 2014
4753AL 8697

Potent and selective p38α inhibitor

Aug 2014
4303PPQ 102

Potent, voltage-independent CFTR chloride channel inhibitor

Aug 2014
4161Paricalcitol

Analog of the active form of vitamin D2

Aug 2014
4148Abacavir hemisulfate

Reverse transcriptase inhibitor; antiretroviral

Aug 2014
5257GSK 137647

Potent and selective FFA4 (GPR120) agonist

Aug 2014
5256AH 7614

Selective FFA4 (GPR120) antagonist

Aug 2014
5134MRT 67307 dihydrochloride

Salt inducible kinase (SIK) inhibitor

Aug 2014
4952TRAM 39

Potent KCa3.1 blocker

Aug 2014
4828LDN 209929 dihydrochloride

Potent and selective haspin kinase inhibitor

Aug 2014
5231MPC 6827 hydrochloride

Inhibitor of microtubule polymerization; antimitotic and antitumor

Aug 2014
5196PMX 205

Potent C5a receptor peptide antagonist

Aug 2014
5191PTC 209

Bmi-1 inhibitor; antitumor

Aug 2014
4150Azidothymidine

Selective reverse transcriptase inhibitor; antiretroviral

Aug 2014
3909Toceranib

Potent PDGFR and VEGFR inhibitor

Aug 2014
52556-Bnz-cAMP sodium salt

Cell permeable cAMP analog

Aug 2014
5247NVP ADW 742

ATP-competitive inhibitor of IGF1R

Aug 2014
5186Neuropathiazol

Selective inducer of neuronal differentiation in hippocampal neural progenitors

Aug 2014
5061RKI 1447 dihydrochloride

Potent and selective ROCK inhibitor; antitumor

Aug 2014
4963SC 144 hydrochloride

gp130 inhibitor; blocks cytokine-triggered gp130 signaling

Aug 2014
5254FH 1

Enhances iPSC-derived hepatocyte differentiation and maturation

Jul 2014
5223Monensin sodium salt

Sodium ionophore; antibacterial agent

Jul 2014
5213LL 37

Antimicrobial peptide derivative of human cathelicidin

Jul 2014
5171NBOH-2C-CN hydrochloride

High affinity, selective 5-HT2A agonist

Jul 2014
5109SB 743921 hydrochloride

Potent kinesin spindle protein (KSP) inhibitor

Jul 2014
5068ITD 1

Selective inhibitor of TGF-β signaling; induces cardiomyocyte differentiation in ESCs

Jul 2014
5250Ramipril

Non-peptide, competitive angiotensin-converting enzyme (ACE) inhibitor

Jul 2014
5173MS 436

Potent and selective BRD4(1) bromodomain inhibitor

Jul 2014
5161ML 154

Potent neuropeptide S receptor (NPSR) antagonist

Jul 2014
4767WAY 316606 hydrochloride

Secreted Frizzled-related protein-1 (sFRP-1) inhibitor; increases Wnt signaling

Jul 2014
4734TRC 051384

Inducer of heat shock protein Hsp70

Jul 2014
5228Urea

Used to solubilize and denature proteins

Jul 2014
5227Tricine

Electrophoresis buffer

Jul 2014
5226Sodium phosphate monobasic

Commonly used in biological assay buffers

Jul 2014
5225Ponceau S Staining Solution

Stain used to detect protein bands after Western blotting

Jul 2014
5224MTT

Reagent used in the measurement of cell proliferation

Jul 2014
5222Hematoxylin

Dye used to stain cell nuclei

Jul 2014
5221Guanidine Hydrochloride

Protein denaturant

Jul 2014
5220Glycerol

Widely used in sample buffer preparation

Jul 2014
5219L-Glutathione Reduced

Endogenous antioxidant

Jul 2014
5218Bromophenol Blue

Dye used in gel loading buffers

Jul 2014
5217Bovine Serum Albumin

Widely used blocking agent for ELISA and blotting

Jul 2014
5216BIS-TRIS

Commonly used buffering agent

Jul 2014
5095DBM 1285 dihydrochloride

p38 MAPK inhibitor; anti-inflammatory

Jul 2014
4993NSC 624206

Ubiquitin-activating enzyme (E1) inhibitor

Jul 2014
4169KS 176

Selective BCRP inhibitor

Jul 2014
4139Aprotinin

Competitive serine protease inhibitor

Jul 2014
3177Boric acid

Widely used in buffers for electrophoresis

Jul 2014
3166Sodium dodecyl sulphate solution

Detergent used in electrophoresis of proteins

Jul 2014
3165Polyoxyethylenesorbitan monolaurate

Detergent used for protein extraction

Jul 2014
3156Dulbecco's PBS

Buffered saline used in mammalian cell culture

Jul 2014
3153Sodium phosphate dibasic

Commonly used in biological assay buffers

Jul 2014
3150Potassium phosphate monobasic

Commonly used in biological assay buffers

Jul 2014
5245Ebselen

Glutathione peroxidase mimic; peroxynitrite scavenger

Jul 2014
5230BRD 7552

PDX1 transcription factor inducer; increases insulin expression

Jul 2014
5184BDS I

Potent and reversible Kv3.4 potassium channel blocker; neuroprotective

Jul 2014
4745LIMKi 3

Potent LIM kinase inhibitor; antitumor

Jul 2014
4694Ro 5-3335

Core binding factor inhibitor; attenuates hematopoiesis

Jul 2014
4625TC OT 39

Potent non-peptide oxytocin receptor partial agonist; also V1a receptor antagonist

Jul 2014
5190FRAX 486

Potent p21-activated kinase (PAK) inhibitor; brain penetrant and orally bioavailable

Jul 2014
5179TCID

Selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor

Jul 2014
5141AZD 5582 dihydrochloride

Dimeric Smac mimetic; potent IAP inhibitor

Jul 2014
50332-MPPA

Selective glutamate carboxypeptidase II (GCP II) inhibitor; orally bioavailable

Jul 2014
4842BIX 02189

Selective MEK5 and ERK5 inhibitor

Jul 2014
4783Lu AA 47070

Prodrug of a potent and selective adenosine A2A receptor antagonist

Jul 2014
4750TC Mps1 12

Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor; orally active

Jul 2014
2472Triacsin C

Inhibitor of acyl-CoA synthetase

Jul 2014
5208E 64

Potent and irreversible cysteine protease inhibitor

Jun 2014
5195Agitoxin 2

Potent Shaker K+ channel blocker

Jun 2014
5181Tolvaptan

Potent and selective vasopressin V2 receptor antagonist; renoprotective and orally active

Jun 2014
5107GSK 2606414

Potent and selective PERK inhibitor; orally bioavailable

Jun 2014
5044SR 3576

Highly potent and selective JNK3 inhibitor

Jun 2014
5198AZ 20

Potent and selective ATR kinase inhibitor; antitumor

Jun 2014
4945ML 347

Potent and selective ALK1 and ALK2 inhibitor

Jun 2014
5199AZD 7762 hydrochloride

Potent and selective ATP-competitive inhibitor of Chk1 and Chk2

Jun 2014
5098KRCA 0008

Potent Ack1 and ALK dual inhibitor; orally bioavailable

Jun 2014
5077DDR1-IN-1 dihydrochloride

Selective DDR1 inhibitor

Jun 2014
4888KHS 101 hydrochloride

Selective inducer of neuronal differentiation in hippocampal neural progenitors

Jun 2014
5086PA 452

RXR antagonist

Jun 2014
5005DR 4485 hydrochloride

High affinity and selective 5-HT7 antagonist; orally bioavailable

Jun 2014
4854ML 00253764 hydrochloride

Melanocortin MC4 receptor antagonist; brain penetrant

Jun 2014
4598PHT 427

Dual Akt and PDK1 inhibitor; antitumor

Jun 2014
5175AEBSF

Broad spectrum, irreversible inhibitor of serine proteases

May 2014
5110GSK 1562590 hydrochloride

High affinity, selective urotensin II (UT) receptor antagonist

May 2014
5051BIO 5192

Highly potent and selective inhibitor of integrin α4β1

May 2014
5021TC-G 1000

Potent and selective α2D agonist

May 2014

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Bio-Techne Events

Pharmacology 2014

Pharmacology 2014

December 16 - 18, 2014

London, UK

Booth Number: 12