New Products

Cat.No.

Product Name / Activity

Positive allosteric modulator of AMPA

Irreversible mitochondrial respiratory complex II inhibitor

Potent inhibitor of Abl T315l mutant and wild-type Abl kinases

Inhibitor of Wnt/β-catenin signaling

Calcium-activated chloride channel (CaCC) inhibitor

Activator of Ca²⁺-activated Cl^- channel transmembrane protein 16A (TMEM16A)

Potent and selective S1P₄ agonist

Geranylgeranyltransferase I (GGTase I) inhibitor

Potent and selective LPA₂ receptor antagonist

Potent K_Ca3.1 channel blocker

Dual IR/IGF1R inhibitor

Selective H₄ agonist

Selective A_2B antagonist

Tankyrase inhibitor; inhibits Wnt signaling

Inhibitor of SCD1; selectively eliminates undifferentiated hPSCs from culture

Reversible inhibitor of MKLP-2

Potent and selective K_V1.3 channel blocker

Mcl-1 inhibitor; proapoptotic

γ-secretease inhibitor; inhibits Notch pathway

Positive allosteric modulator of GluA2 receptors

Inhibits TRPP3-mediated currents; also inhibits the Na⁺/H⁺ exchanger (NHE)

Potent and selective GlyT2 inhibitor

FFA1 (GPR40) agonist. Also inhibits ATP citrate lyase

Potent, selective CCR1 antagonist

Cyclin-dependent kinase inhibitor

Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645)

Potent, selective LRRK2 inhibitor; brain penetrant

Selective cathepsin B inhibitor

Inhibitor of TBK1 and IKKε; antiallergic agent

Oxytocin analog

Potent and selective dual PI 3-kinase/mTOR inhibitor

Aurora kinase A and B inhibitor

Dual PI 3-K/mTOR inhibitor

Potent and selective EP₂ receptor antagonist

Selective Bax activator; induces Bax-mediated apoptosis

HIF pathway activator

Inhibitor of IP6K; also inhibits IP3K

Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest

FP prostaglandin receptor agonist; also exhibits agonist activity at EP₁ and EP₃ receptors

Synthetic progesterone analog

Fluorescent cytochrome P450 substrate

Selective IKKα and IKKβ inhibitor

Histone deacetylase inhibitor

ASIC3 channel blocker

AT₁ receptor antagonist

Selective LPA₂ receptor non-lipid agonist

Apelin receptor (APJ) antagonist

Positive allosteric modulator of α7 nAChR

Nrf2 pathway activator; blocks Nrf2/Keap1 interaction

Prodrug of candesartan (Cat. No. 4791), an AT₁ receptor antagonist

Negative allosteric modulator at PAR₁ receptor

PAR₂ peptide antagonist

Activator of TRPML channels

Potent antagonist of α_vβ₃-vitronectin interaction; antiangiogenic

Potent and selective S1P₄ agonist

Biotinylated Pam2CSK4 (Cat. No. 4637)

Biotinylated Pam3CSK4 (Cat. No. 4633)

Potent, high affinity CB₁ receptor inverse agonist

Potent NK₁ receptor antagonist

Potent and selective p38α inhibitor

Inhibits Hedgehog signaling

Highly potent and selective DOT1L inhibitor; cell permeable

Selective serotonin reuptake inhibitor (SSRI)

Selective GPR30 antagonist

Calcium sensing receptor (CaSR) agonist

Binds mot-2; selectively cytotoxic in cancer cells

Selective S1P₁ agonist

Selective negative allosteric modulator of group II mGlu receptors

NAADP antagonist; inhibits Ca²⁺ release

Prodrug of 5-Fluorouracil (Cat. No. 3257). Inhibits DNA synthesis

Potent 5-HT and NE reuptake inhibitor; also blocks dopamine reuptake

Potent, selective Cdk4/6 inhibitor; brain penetrant

Cyclooxygenase-inhibiting nitric oxide donor

Selective SIRT2 inhibitor; brain penetrant

Selective inhibitor of PI 3-Kinase γ

Urotensin-II (UT) antagonist; attenuates cardiac dysfunction

Selective melanin-concentrating hormone receptor 1 (MCH₁R) antagonist

Inhibits TRPP3-mediated currents; also inhibits epithelial Na⁺ channels

TrkB receptor antagonist

Induces G₂/M cell cycle arrest; anticancer

Promotes differentiation of human ESCs and iPSCs into cardiomyocytes

Inhibitor of Hedgehog (Hh) signaling; binds directly to Smo

Negative allosteric modulator of 5-HT₃

Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation

High affinity thyroid receptor α (TRα) and TRβ agonist; thyromimetic

NCX inhibitor, Deg/ENaC channel blocker; amiloride (Cat. No. 0890) derivative

Selective inhibitor of OXE-R Gβγ signaling

Protein kinase C inhibitor; selective for β isozymes

Potent inhibitor of interleukin-2 inducible T cell kinase (ITK). Also inhibits BTK

Highly potent and selective OX₂ antagonist; brain penetrant

Na⁺/Ca²⁺ exchange inhibitor (reverse mode); neuroprotective

Potent, selective BET bromodomain inhibitor; cell permeable

Selective 5-HT_2A antagonist

Negative allosteric modulator at mGlu₅

Mood stabilizer; inhibits Na⁺/K⁺ ATPase pump activity

USP7 inhibitor

TRPV1 antagonist; displays in vivo activity

Inhibits Smoothened (Smo) accumulation

REV-ERBα antagonist

Pan kinase inhibitor; potently inhibits MEK-1

Stretch-activated calcium channel blocker; calcium-sensing receptor agonist

Potassium channel blocker; neuroprotective

ALDH1a2 inhibitor

5-HT₂/D₂ antagonist; atypical antipsychotic

Glycoprotein IIa/IIIb inhibitor; inhibits platelet aggregation

Enables Wnt/β-catenin-driven expansion of ESCs; prevents spontaneous differentiation

Potent and selective L3MBTL3 domain inhibitor; cell permeable

Potent and selective GPR120 agonist

Selective T-LAK-cell-originated protein kinase (TOPK) inhibitor

Selective OX₂ receptor antagonist

Constitutive androstane receptor (CAR) agonist

Selectively inhibits PKC-induced NF-κB activation

Selective TRPC4 blocker

PMAT inhibitor

Selective 5-HT₇ ligand

TLR2/6 agonist; induces TNF-α production

TLR1/2 agonist; induces cytokine production

Potent NPY Y₂ receptor antagonist

Potent JAK inhibitor

5-HT_2C inverse agonist; α₂ antagonist

Histone demethylase inhibitor; cell permeable

Selective α3β4 nAChR antagonist

HIF-1α inhibitor; down-regulates HIF-1α protein synthesis

Potent and selective mTOR inhibitor

Selective TRPA1 channel blocker

Furin inhibitor

Potent CXCR4 antagonist

Inhibitor of BCRP-mediated multidrug resistance

Potent COMT inhibitor; blocks α-synuclein aggregation

Caged GABA; inhibits neural activity

Inhibits TCF-dependent transcription; lowers β-catenin levels

Sphingosine kinase inhibitor

Potent and selective 17β-hydroxysteroid dehydrogenase type 3 inhibitor

Potent and selective ERK2 inhibitor

High affinity PPARγ ligand; blocks Cdk5-dependent PPARγ phosphorylation

Selective P2X₃, P2X_2/3 antagonist

Protein kinase C activator

Selective CB₁ receptor antagonist

Selective Na_V 1.7 channel blocker

Long-acting β₂ agonist; bronchodilator

Ca_V3.1 channel blocker; also inhibits Na_V1.8 and K_V2.1

DNA alkylating agent; cytotoxic and antineoplastic

Potent LRRK2 inhibitor; neuroprotective

Cytotoxic nucleoside analog; inhibits RNA synthesis

Potent PKC inhibitor and nicotinic receptor antagonist

Stabilizes F-actin; promotes actin polymerization