 |
Welcome to Tocris |
View Basket | Checkout
| Log In
|
| Home | Products | Technical Support | Customer Support | Literature | Custom Synthesis |
|
Tocrisolve Tocrisolve – New Technology for Solubilization in Water Many cannabinoid and vanilloid receptor ligands are water-insoluble fatty-acid-based structures. However, new technologies have now enabled chemists to synthesize these ligands in a water-soluble emulsion format, Tocrisolve 100.What is Tocrisolve 100? Tocrisolve 100 is a water-soluble (or dispersible) emulsion composed of a 1:4 ratio of soya oil/water. The formulation is emulsified with the block co-polymer Pluronic F68 and can be diluted with any aqueous medium.How does Tocris Add the Cannabinoid to the Emulsion? The cannabinoid or vanilloid is incorporated with the emulsion as part of a specialized innovative production process. The soya oil forms a coating around the cannabinoid molecule, and the block co-polymer is added to stabilize the emulsion, preventing the lipid droplets from coalescing (merging) in the surrounding water.Can I Use Cannabinoids in Tocrisolve for My Usual Experiments? The emulsion can be diluted to any extent with aqueous medium, including water, saline and HEPES buffer. The solution can be used for in vitro or in vivo experiments, as has been reported for anandamide (in Tocrisolve 100) in the following papers:Gardiner et al (2002) Complex regional haemodynamic effects of anandamide in conscious rats. Br.J.Pharmacol. 135 1889. |
Tocris Bioscience Launches New Unique & Affordable Screening Library (more). Upcoming ConferencesENDO Annual Meeting |
